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- Title
Effect of low-level laser therapy after implantation of poly-L-lactic/polyglycolic acid in the femurs of rats.
- Authors
Freddo, Angelo; Rodrigo, Simone; Massotti, Fabrício; Etges, Adriana; Oliveira, Marília; Freddo, Angelo Luiz; Rodrigo, Simone Marja; Massotti, Fabrício Poletto; de Oliveira, Marília Gerhardt
- Abstract
This study evaluated the use of red and infrared lasers on tissue surrounding the femurs of 60 rats randomly divided into three groups after implantation of bioabsorbable plates. The control group were not subjected to laser irradiation; group A was treated with red laser [indium-gallium-aluminum-phosphide (InGaAlP) laser, wavelength 685 nm, 35 mW, continuous wave (CW), Ø = 0.06 cm, 2.23 min], and group B was subjected to infrared laser [gallium-aluminum-arsenium (GaAlAs) laser, wavelength 830 nm, 50 mw, CW, Ø = 0.06 cm, 1.41 min], both at 10 J/cm(2). Samples were stained with hematoxylin and eosin (H&E) and examined microscopically. Results showed that the laser irradiation had had a positive photobiomodulation effect on inflammation, confirmed by a better histologic pattern than that of the control group at 3 days and 7 days. Semiquantitative analysis revealed that groups A and B had a histologic score significantly greater than that of the control group at 3 days. At 21 days, histomorphometric analysis revealed a more intense inflammation in the red laser group than in the other groups. We concluded that low-level laser therapy (LLLT) has positive effects on the photobiomodulation of inflammation in the tissues surrounding the poly-L-lactic/polyglycolic acid (PLLA/PGA) bioabsorbable plate. It stimulated vascularization, fibroblast proliferation, and collagen deposition.
- Subjects
LASER therapy; INFRARED equipment; LABORATORY rats; BIOFRAGMENTABLE anastomosis rings; ARTIFICIAL implants; IRRADIATION; FEMUR surgery; INFLAMMATION prevention; ANIMAL experimentation; BIOLOGICAL models; BIOMEDICAL materials; BONE regeneration; COMPARATIVE studies; FEMUR; INFLAMMATION; LACTIC acid; MATERIALS testing; RESEARCH methodology; MEDICAL cooperation; ORTHOPEDIC implants; POLYESTERS; RATS; RESEARCH; OSSEOINTEGRATION; EVALUATION research; PHYSIOLOGICAL effects of radiation
- Publication
Lasers in Medical Science, 2009, Vol 24, Issue 5, p721
- ISSN
0268-8921
- Publication type
journal article
- DOI
10.1007/s10103-008-0627-2