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- Title
Skin immune sentinels in health and disease.
- Authors
Nestle, Frank O.; Di Meglio, Paola; Qin, Jian-Zhong; Nickoloff, Brian J.
- Abstract
Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103(+) dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.
- Subjects
HUMAN anatomy; SKIN diseases; CELLULAR immunity; KERATINOCYTES; DENDRITIC cells; ANTIGEN presenting cells
- Publication
Nature Reviews Immunology, 2009, Vol 9, Issue 10, p679
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2622