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- Title
Topical ivermectin ointment treatment of Demodex blepharitis: a 6-year retrospective study.
- Authors
Valvecchia, Florencia; Greco, Lourdes; Perrone, Franco; Logioco, Celina; Caride, Gaston Gomez; Perrone, Luciano; Valvecchia, Gerardo; Albertazzi, Roberto; Zanutigh, Virginia
- Abstract
Background: To evaluate the efficacy of topical ivermectin 1% ointment, for the treatment of Demodex blepharitis. Methods: A retrospective study was designed to review electronic medical records of patients seen between January 2017 and December 2022, who had a diagnosis of Demodex blepharitis, treated with topical ivermectin 1% with at least 6 months of follow-up (Centro de Ojos Quilmes, Buenos Aires, Argentina). The presence of collarettes was graded from 0 to 4. An imaging system (Keratograph) was used, to evaluate tear meniscus height (TMH), non-invasive tear break-up time (NIKBUT), and degree of conjunctival redness. In addition, the ocular surface disease index (OSDI) test was performed. Results were compared before and after ivermectin treatment, which was performed once a day for 2 months. Results: A total of 2157 patients (4314 eyes) were included. The mean age was 50.43 ± 15.3 years, and the follow-up time was 26.1 ± 8.5 months. No one discontinued treatment due to intolerance, although 14 cases (0.6 %) reported occasional discomfort. The grade of collarettes decreased with statistical significance, from 3.37 ± 0.7 to 0.1 ± 0.3 (p < 0.01), as well as conjunctival redness from 1.32 ± 0.3 to 0.94 ± 0.4 (p < 0.01) and OSDI score from 58.74 ± 17.9 to 17.1 ± 10.5 (p = 0.02). TMH and NIKBUT improved without statistical difference. Conclusion: Treatment with ivermectin 1% topical ointment, once daily for 2 months, was effective in reducing the presence of collarettes and in improving symptoms in patients with Demodex blepharitis.
- Subjects
BUENOS Aires (Argentina); DEMODEX; IVERMECTIN; BLEPHARITIS; ELECTRONIC health records; RETROSPECTIVE studies
- Publication
Graefe's Archive of Clinical & Experimental Ophthalmology, 2024, Vol 262, Issue 4, p1281
- ISSN
0721-832X
- Publication type
Article
- DOI
10.1007/s00417-023-06281-0