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- Title
Clinical outcomes of endoscopic resection for the treatment of intermediate- or high-risk gastric small gastrointestinal stromal tumors: a multicenter retrospective study.
- Authors
Xu, Enpan; Shi, Qiang; Qi, Zhipeng; Li, Bing; Sun, Huihui; Ren, Zhong; Cai, Shilun; He, Dongli; Lv, Zhengtao; Chen, Zhanghan; Zhong, Liang; Xu, Leiming; Li, Xiaobo; Xu, Shuchang; Zhou, Pinghong; Zhong, Yunshi
- Abstract
Background and aims: Many studies of gastric gastrointestinal stromal tumors (g-GISTs) following endoscopic resection (ER) have typically focused on tumor size, with most tumors at low risk of aggressiveness after risk stratification. There have been few systematic studies on the oncologic outcomes of intermediate- or high-risk g-GISTs after ER. Methods: From January 2014 to January 2020, we retrospectively collected patients considered at intermediate- or high-risk of g-GISTs according to the modified NIH consensus classification system. The primary outcome was overall survival (OS). Results: Six hundred and seventy nine (679) consecutive patients were diagnosed with g-GISTs and treated by ER between January 2014 and January 2020 in three hospitals in Shanghai, China. 43 patients (20 males and 23 females) were confirmed at intermediate-or high-risk. The mean size of tumors was 2.23 ± 1.01 cm. The median follow-up period was 62.02 ± 15.34 months, with a range of 28 to 105 months. There were no recurrences or metastases, even among patients having R1 resections. The 5-year OS rate was 97.4% (42/43). Conclusion: ER for intermediate- or high-risk gastric small GISTs is a feasible and safe method, which allows for a wait-and-see approach before determining the necessity for imatinib adjuvant or surgical treatment. This approach to g-GISTs does require that patients undergo close follow-up.
- Subjects
CHINA; GASTROINTESTINAL tumors; RISK assessment; CONSENSUS (Social sciences); STOMACH tumors; CANCER relapse; BODY mass index; T-test (Statistics); RESEARCH funding; NATIONAL Institutes of Health (U.S.); FISHER exact test; TREATMENT effectiveness; RETROSPECTIVE studies; HOSPITALS; DESCRIPTIVE statistics; CHI-squared test; SYMPTOMS; SURGICAL complications; METASTASIS; ADJUVANT chemotherapy; LOG-rank test; KAPLAN-Meier estimator; ENDOSCOPIC gastrointestinal surgery; RESEARCH; MEDICAL records; ACQUISITION of data; ANALYSIS of variance; IMATINIB; DATA analysis software; COMPARATIVE studies; OVERALL survival; COMORBIDITY; EVALUATION; DISEASE risk factors
- Publication
Surgical Endoscopy & Other Interventional Techniques, 2024, Vol 38, Issue 6, p3353
- ISSN
1866-6817
- Publication type
Article
- DOI
10.1007/s00464-024-10753-7