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- Title
Prepregnancy maternal body mass index and venous thromboembolism: a population-based cohort study.
- Authors
Butwick, AJ; Bentley, J; Leonard, SA; Carmichael, SL; El‐Sayed, YY; Stephansson, O; Guo, N; Butwick, A J; Leonard, S A; Carmichael, S L; El-Sayed, Y Y
- Abstract
<bold>Objective: </bold>To assess the relation between maternal body mass index (BMI) and pregnancy-related venous thromboembolism (VTE).<bold>Design: </bold>Cohort study.<bold>Setting and Population: </bold>A total of 2 449 133 women with singleton pregnancies who underwent delivery hospitalisation in California between 2008 and 2012.<bold>Methods: </bold>Association of pre-pregnancy BMI and the risk of an antepartum and postpartum VTE was examined using logistic regression, with normal BMI as reference.<bold>Main Outcome Measures: </bold>Antepartum and postpartum VTE-related hospitalisation.<bold>Results: </bold>The prevalence of antepartum and postpartum VTE increased with increasing BMI (antepartum: 2.3, 3.0, 3.8, 4.2, 4.7, and 10.6 per 10 000 women for underweight, normal BMI, overweight, obesity class I, II, and III, respectively, P < 0.001; postpartum: 2.0, 3.1, 3.9, 5.6, 9.0, and 13.2 per 10 000 women, P < 0.01). The adjusted odds of antepartum and postpartum VTE increased progressively with increasing BMI, with obesity class III women having the highest risk of pregnancy-related VTE compared with normal BMI women: adjusted odds ratio for antepartum VTE: 2.9; 95% CI 2.2-3.8 and adjusted odds ratio for postpartum VTE: 3.6; 95% CI 2.9-4.6.<bold>Conclusions: </bold>Our findings clearly demonstrate an increasing risk of pregnancy-related VTE with increasing BMI.<bold>Tweetable Abstract: </bold>Obesity was associated with increased odds of antepartum and postpartum venous thromboembolism.
- Subjects
CALIFORNIA; BODY mass index; THROMBOEMBOLISM; COHORT analysis; ODDS ratio; LOGISTIC regression analysis; OBESITY complications; CARDIOVASCULAR diseases in pregnancy; QUESTIONNAIRES; RESEARCH funding; VEINS; DISEASE prevalence; RETROSPECTIVE studies
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2019, Vol 126, Issue 5, p581
- ISSN
1470-0328
- Publication type
journal article
- DOI
10.1111/1471-0528.15567