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- Title
Synthesis, enzyme inhibition, and molecular docking studies of a novel chalcone series bearing benzothiazole scaffold.
- Authors
Musatat, Ahmad Badreddin; Atahan, Alparslan; Ergün, Adem; Çıkrıkcı, Kübra; Gençer, Nahit; Arslan, Oktay; Zengin, Mustafa
- Abstract
This study reports the facile synthesis of a novel series of benzothiazole‐chalcones, in addition to their inhibitory profile on important metabolic enzymes including human carbonic anhydrases (hCA‐I, hCA‐II) and paraoxonase (PON‐1). The inhibition parameters, IC50 (concentration for 50% inhibition) and Ki (dissociation constant) values, toward the title enzymes were determined for the studied compounds. As a result, IC50 values of hydratase activity were in the range 4.15–5.47 and 2.56–4.58 μM for hCA‐I and hCA‐II, respectively. At the same time, IC50 values of esterase activity were in the range 24.91–104.00 and 35.25–97.00 μM, while Ki values were in the range 14.43–59.66 and 26.65–73.34 μM for hCA‐I and hCA‐II, respectively. In addition, PON‐1 enzyme inhibition results showed interesting inhibitory effects, with IC50 values between 13.28 and 16.68 μM. Finally, a comprehensive approach was established for the synthesized compounds based on theoretical calculations, which have been done using B3LYP, PBE0 theories and SVP, TVZP, TVZPP basis sets, followed by docking studies by which the outputs proved the harmonically flows with the experimental results.
- Subjects
CHALCONE; MOLECULAR docking; BENZOTHIAZOLE; ENZYMES; CARBONIC anhydrase; CHEMICAL synthesis
- Publication
Biotechnology & Applied Biochemistry, 2023, Vol 70, Issue 3, p1357
- ISSN
0885-4513
- Publication type
Article
- DOI
10.1002/bab.2445