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- Title
Stromal Modulators of TGF-β in Cancer.
- Authors
Costanza, Brunella; Umelo, Ijeoma Adaku; Bellier, Justine; Castronovo, Vincent; Turtoi, Andrei
- Abstract
Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in malignant disease. It is an important mediator of cancer invasion, metastasis and angiogenesis, on the one hand, while it exhibits anti-tumor functions on the other hand. Elucidating the precise role of TGF-β in malignant development and progression requires a better understanding of the molecular mechanisms involved in its tumor suppressor to tumor promoter switch. One important aspect of TGF-β function is its interaction with proteins within the tumor microenvironment. Several stromal proteins have the natural ability to interact and modulate TGF-β function. Understanding the complex interplay between the TGF-β signaling network and these stromal proteins may provide greater insight into the development of novel therapeutic strategies that target the TGF-β axis. The present review highlights our present understanding of how stroma modulates TGF-β activity in human cancers.
- Subjects
MOLECULAR oncology; CANCER invasiveness; TRANSFORMING growth factors; CYTOKINES; METASTASIS; NEOVASCULARIZATION
- Publication
Journal of Clinical Medicine, 2017, Vol 6, Issue 1, p7
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm6010007