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- Title
MUC5AC in juvenile conjunctival nevus.
- Authors
Lin, Hsin-Chiung; Chu, Pao-Hsien; Jung, Shih-Ming; Yang, Meng-Ling; Ma, David
- Abstract
Purpose: To evaluate the possible role of cysts with mucins and inflammatory cells in rapid-growing juvenile conjunctival nevus. Methods: This was a case-control study at a university-based referral clinic. Seventeen conjunctival melanocytic lesions surgically excised from patients aged <20 years between 2001 and 2009 were examined by hematoxylin-eosin, periodic acid-Schiff, MUC5AC, and Alcian blue staining. The clinical signs of the affected patients and the histological findings were characterized. Results: Eleven patients (3 girls and 8 boys; mean age 13.72 ± 3.60 years) underwent excision of a conjunctival nevus that had grown rapidly within a recent 6-month period. We found a significantly higher number of prominent cysts with mucins in the rapid-growing specimens than in the stable-growing control specimens ( n = 6; 33.7 ± 19.9 vs. 0.9 ± 0.9%, P = 0.0005). However, the numbers of inflammatory cells were not statistically significantly different (42.17 ± 15.46 vs. 45.55 ± 16.31, P = 0.683). Conclusions: The period of rapid growth of juvenile conjunctival nevus is not a malignant clinical sign. Although it might correlate with enlarged cysts lined by goblet cells associated with mucin secretions, the number of inflammatory cells remains relatively stable over time.
- Subjects
MUCINS; MUCOPROTEINS; CONJUNCTIVA diseases; PATIENTS; INFLAMMATION
- Publication
Japanese Journal of Ophthalmology, 2012, Vol 56, Issue 2, p107
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-011-0109-0