We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nonparametric Parameters of 24-Hour Rest-Activity Rhythms and Long-Term Cognitive Decline and Incident Cognitive Impairment in Older Men.
- Authors
Xiao, Qian; Sampson, Joshua N; LaCroix, Andrea Z; Shadyab, Aladdin H; Zeitzer, Jamie M; Ancoli-Israel, Sonia; Yaffe, Kristin; Stone, Katie; Group, Osteoporotic Fractures in Men (MrOS) Study; Osteoporotic Fractures in Men (MrOS) Study Group
- Abstract
Altered 24-hour rest-activity rhythms may be associated with cognitive impairment in older adults, but evidence from prospective studies is limited. Nonparametric methods were used to assess actigraphy-based activity patterns in 2 496 older men. Incident cognitive impairment was assessed 4 times over 12 years using the Modified Mini-Mental State Examination (3MS) and Trails B tests, self-reported medication use, and clinical diagnosis. The highest quartile (vs the lowest) of intradaily variability and the lowest quartiles (vs the highest) of interdaily stability and relative amplitude were associated with incident cognitive impairment (hazard ratio [95% confidence interval]: 1.82 [1.31-2.53], 1.36 [0.99-1.86], and 1.85 [1.33-2.56], respectively). A larger increase in intradaily variability over 7.5 years was associated with a greater subsequent decline in 3MS scores but not in Trails B performance. In conclusion, less stable and more variable rest-activity rhythms may represent early biomarkers of cognitive impairment in older men.
- Subjects
OLDER men; COGNITION disorders; OLDER people; RHYTHM; MINI-Mental State Examination; EMOTIONAL stability
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2022, Vol 77, Issue 2, p250
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glab275