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- Title
Comparative Approaches to Understanding the Relation Between Aging and Physical Function.
- Authors
Justice, Jamie N.; Cesari, Matteo; Seals, Douglas R.; Shively, Carol A.; Carter, Christy S.
- Abstract
Despite dedicated efforts to identify interventions to delay aging, most promising interventions yielding dramatic life-span extension in animal models of aging are often ineffective when translated to clinical trials. This may be due to differences in primary outcomes between species and difficulties in determining the optimal clinical trial paradigms for translation. Measures of physical function, including brief standardized testing batteries, are currently being proposed as biomarkers of aging in humans, are predictive of adverse health events, disability, and mortality, and are commonly used as functional outcomes for clinical trials. Motor outcomes are now being incorporated into preclinical testing, a positive step toward enhancing our ability to translate aging interventions to clinical trials. To further these efforts, we begin a discussion of physical function and disability assessment across species, with special emphasis on mice, rats, monkeys, and man. By understanding how physical function is assessed in humans, we can tailor measurements in animals to better model those outcomes to establish effective, standardized translational functional assessments with aging.
- Subjects
PHYSICAL activity; AGING; TRANSLATIONAL research; LIFE spans; CLINICAL trials; GERIATRIC assessment; BIOLOGICAL models; FUNCTIONAL assessment; GERIATRICS; LONGEVITY; PRIMATES; RESEARCH funding
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2016, Vol 71, Issue 10, p1243
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glv035