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- Title
Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas.
- Authors
Young Hwa Soung; Jong Woo Lee; Su Young Kim; Won Sang Park; Suk Woo Nam; Jung Young Lee; Nam Jin Yoo; Sug Hyung Lee
- Abstract
Mounting evidence indicates that deregulation of apoptosis is involved in the mechanisms of cancer development. Caspase-9 plays a crucial role in the initiation phase of the intrinsic apoptosis pathway. To explore the possibility that the genetic alterations of caspase-9 might be involved in the development of human cancers, we analyzed the entire coding region and all splice sites of the human caspase-9 gene for the detection of somatic mutations in a series of 353 cancers, including 180 gastric, 104 colorectal and 69 lung adenocarcinomas. Overall, we detected three somatic mutations of caspase-9, but all of the mutations were silent mutations. The mutations were observed in 2 of 104 colorectal carcinomas and 1 of 180 gastric carcinomas. These data indicate that the caspase-9 gene is rarely mutated in gastric, colorectal and lung adenocarcinomas, and suggest that caspase-9 gene mutation may not contribute to the pathogenesis of these cancers.
- Subjects
APOPTOSIS; ANTIBODY diversity; GENETIC mutation; GENES; CARCINOGENESIS
- Publication
APMIS, 2006, Vol 114, Issue 4, p292
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1600-0463.2006.apm_364.x