We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Helicobacter pylori Infection and Peptic Ulcer Disease in Symptomatic Children in Southern Vietnam: A Prospective Multicenter Study.
- Authors
Nguyen, Tu Cam; Tang, Ngoc Le Chau; Le, Giao Kim Ngoc; Nguyen, Vy Thuy; Nguyen, Khuong Hoang Gia; Che, Thai Hoang; Phan, Van Thi Tuong; Nguyen, Ngoc Minh; Truong, Dinh Quang; Ngo, Xuan Minh; Nguyen, Hiep Thanh; Robert, Annie; Bontems, Patrick; Nguyen, Phuong Ngoc Van
- Abstract
Background: Helicobacter pylori (H. pylori) remains a major cause of gastroduodenal diseases. We aimed to evaluate the burden of this infection, particularly peptic ulcer disease in Vietnamese children. Methods: We enrolled consecutive children referred for esophagogastroduodenoscopy at two tertiary children's hospitals in Ho Chi Minh City, from October 2019 to May 2021. Children treated with proton pump inhibitors during the last two weeks or antibiotics for four weeks, and those having a previous or interventional endoscopy were excluded. H. pylori infection was diagnosed with either a positive culture or positive histopathology combined with a rapid urease test, or with a polymerase chain reaction of the urease gene. The study was approved by the Ethics Committee and written informed consent/assent was obtained. Results: Among 336 enrolled children aged 4–16 (mean: 9.1 ± 2.4 years; 55.4% girls), H. pylori infection was positive in 80%. Peptic ulcers were detected in 65 (19%), increasing with age, and 25% with anemia. cagA+ strains were detected at a higher rate in children with ulcers. Conclusions: Prevalence of H. pylori and peptic ulcers is high among symptomatic Vietnamese children. It is crucial to have a program for early detection of H. pylori to reduce ulcer risk and gastric cancer later.
- Subjects
VIETNAM; ANTIBIOTICS; RESEARCH; CONFIDENCE intervals; MULTIPLE regression analysis; DIGESTIVE system endoscopic surgery; TERTIARY care; FISHER exact test; PROTON pump inhibitors; RESEARCH funding; DESCRIPTIVE statistics; CHI-squared test; PEPTIC ulcer; POLYMERASE chain reaction; DATA analysis software; ODDS ratio; HELICOBACTER diseases; LONGITUDINAL method
- Publication
Healthcare (2227-9032), 2023, Vol 11, Issue 11, p1658
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare11111658