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- Title
Efficacy and Safety of Korean Herbal Medicine for Patients with Post-Accident Syndrome, Persistent after Acute Phase: A Pragmatic Randomized Controlled Trial.
- Authors
Hwang, Bo-Kyung; Park, Kyoung Sun; Ku, Seung-Hyeok; Kim, Sung-Hyun; Moon, Hyun-Woo; Park, Mi-So; Baek, Hye-Kyung; Namgoong, Jin; Hwangbo, Seung-Yoon; Seo, Ji-Yeon; Lee, Yoon Jae; Lee, Jinho; Ha, In-Hyuk
- Abstract
This is a pragmatic, two-armed, parallel, single-center, randomized controlled clinical trial for comparative evaluation between the effectiveness of integrated Korean medicine (IKM) and herbal medicine treatment with that of IKM monotherapy (control) for post-accident syndrome persistent after the acute phase. Participants were randomized into Herbal Medicine (HM, n = 20) and Control groups (n = 20) to receive the allocated treatment of 1–3 sessions/week for 4 weeks. Intention-to-treat analysis was conducted. The Difference of Numeric Rating Scale (NRS) change of overall post-accident syndromes from baseline to week 5 for the two groups was 1.78 (95% CI: 1.08–2.48; p < 0.001). Regarding secondary outcomes, a significant decrease compared to the baseline values was confirmed for NRS of musculoskeletal, neurological, psychiatric complaints and general symptoms of post-accident syndromes. In a survival analysis based on the recovery criteria of "patients with a reduction in the NRS of overall post-accident syndromes of ≥50%," the HM group showed a shorter time to recovery than the control group during the 17-week study period (p < 0.001 by the log-rank test). IKM combined with herbal medicine treatment significantly improved the quality of life by relieving somatic pain and alleviating the overall post-accident syndrome persistent after the acute phase; this effect was maintained for at least 17 weeks.
- Subjects
SOUTH Korea; DRUG efficacy; HERBAL medicine; WHIPLASH injuries; TRAFFIC accidents; CONFIDENCE intervals; RANDOMIZED controlled trials; DESCRIPTIVE statistics; STATISTICAL sampling; PATIENT safety
- Publication
Healthcare (2227-9032), 2023, Vol 11, Issue 4, p534
- ISSN
2227-9032
- Publication type
Article
- DOI
10.3390/healthcare11040534