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- Title
右美托咪定联合七氟烷对心脑血管介入患者血液动力学及苏醒影响.
- Authors
李德平; 薛 韬; 王悦喜; 张迎军; 李 鹏
- Abstract
Objective: To investigate the effects of dexmedetomidine combined with sevoflurane on hemodynamics in patients undergoing cardiovascular and cerebrovascular intervention, and to analyze the effect of drugs on patients' wake-up intervention.Methods: 92 patients who with cardiovascular and cerebrovascular diseases underwent interventional therapy in our hospital from March 2015 to March 2019 were randomly divided into study group and control group (46 cases in each group), ccording to the random number table method. Patients in the control group were anesthetized with sevoflurane and continuously pumped with normal saline. Patients in the study group were treated with sevoflurane combined with dexmedetomidine. The heart rate Heart rate (HR) and Mean arterial pressure (MAP) of T0, T1, T2, S1, S2, and S3 were compared between the two groups. Riker sedation and agitation score (SAS) and extubation time were compared between the two groups. (1) The comparison showed that there was no significant difference in HR and MAP between the two groups at T0 (P>0.05). The HR and MAP of the study group at T1 and T2 were significantly lower than those of the control group (P<0.05).(2) There was no significant difference in HR and MAP between the two groups at S1 (P>0.05). The HR and MAP of the study group at S2 and S3 were significantly lower than those of the control group (P<0.05). (3) The SAS score of the study group was lower than that of the control group when the patient was awakened, and the extubation time was shorter than that of the control group (P<0.05). (4) The incidence of cardiovascular events during the follow-up of the observation group was 10.87%, which was significantly lower than 28.26% of the control group (P<0.05). At the same time, 1 patient died during the two follow-up periods. Conclusion: Interventional therapy for patients with cardiovascular and cerebrovascular diseases can significantly stabilize the hemodynamics of patients with dexmedetomidine combined with sevoflurane. It can also improve the patient's recovery state and relieve the stress response of patients with the weakening of anesthesia, and reduce the occurrence of cardiovascular and cerebrovascular events and improve the prognosis.
- Subjects
HEART beat; PHARMACOLOGY; CARDIOVASCULAR diseases; RANDOM numbers; HEMODYNAMICS; CEREBROVASCULAR disease
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 5, p914
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.05.025