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- Title
慢性肾小球肾炎患者血清UA、Cys C、TAFI联合检测的临床意义.
- Authors
王春花; 秦兰芳; 胡文博; 王宁宁; 罗玉霞
- Abstract
Objective: To analyze the value of combined detection of serum uric acid (UA), serum cystatin C (Cys C) and serum thrombin activated fibrinolytic inhibitor (TAFI) in the early diagnosis of chronic glomerulonephritis (CGN). Methods: 80 patients with CGN who were admitted to Nephrology Department of Qinghai People's Hospital from October 2016 to October 2018 were selected as study group, and 70 cases of healthy patients (control group) who underwent physical examination in our hospital during the same period were selected as the research objects. The UA, Cys C, TAFI and glomerular filtration rate (GFR) levels between the two groups were compared. Pearson correlation analysis was used to analyze the correlation between GFR and UA, Cys C, TAFI. The diagnostic value of each index and combined detection for CGN was compared by receiver operating characteristics (ROC) curve. Results: Compared with the control group, the levels of UA, Cys C and TAFI in serum of the study group increased, while the levels of GFR decreased, the difference was statistically significant (P<0.05). Pearson correlation analysis showed that GFR was negatively correlated with UA, Cys C and TAFI in CGN patients (P<0.05). The sensitivity and specificity of combined detection of serum UA, Cys C and TAFI were 86.3% and 80.0% respectively, which were significantly higher than that of single application of UA, Cys C and TAFI. Conclusion: The levels of UA, Cys C and TAFI in serum of patients with CGN are increased. The combined detection of these three factors is helpful for the clinical early diagnosis of CGN.
- Subjects
RECEIVER operating characteristic curves; GLOMERULAR filtration rate; URIC acid; STATISTICAL correlation; THROMBIN
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 2, p375
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.02.037