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- Title
在体单向肠灌流模型研究白芷中三种成分的吸收特性.
- Authors
闫涛; 王琴会; 姜维; 陈曦; 赵美; 刘新友
- Abstract
Objective: To investigate absorption mechanism of imperatorin, isoimperatorin and methoxsalen in radix of Angelicae dahuricae. Methods: In situ single pass intestinal perfusion model was established, HPLC was used to determine the change of the concentration of imperatorin, isoimperatorin and xanthotoxol in different segments. The absorption parameters of these three analytes in different intestinal segments were investigated. Results: With the increasing of doses for these three analytes, the absorption rate constant (Ka) and effective permeability coefficient (Peff) were increased. There were no significant differences in different segments of intestine in rat. The absorption order was imperatorin, isoimperatorin and xanthotoxol. Conclusion: Radix of Angelicae dahuricae was easily absorbed in the intestine, the degree of absorption was dose-dependent.
- Subjects
INTESTINAL absorption; PERFUSION; ANGELICA (Plants); HIGH performance liquid chromatography; LABORATORY rats; THERAPEUTICS
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 17, p3238
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.17.009