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- Title
MicroRNA-203 在结直肠癌研究中的进展.
- Authors
彭易; 彭秀达; 刘龙飞; 卢先州; 彭扬娥; 李峰; 周筱筠
- Abstract
Colorectal cancer is a common gastrointestinal malignancy in our country. It is accepted that the etiology of colorectal cancer is a multi-factor and multi-step process. However, the mechanism of CRC is still unclear. Micro-RNAs (miRNA) are short noncoding RNAs and function as a negative regulator of gene expression at post-transcriptional level, participating in tumor cell proliferation, invasion, migration and even drug resistance. It is accepted that mir-203 acts as a tumor suppressor. However, its expression in colon cancer is still a controversy. The implication of Mir-203 in various cellular biological activities including tumorigenesis, progression, diagnose, prognosis, chemoresistance will be summarized in this article With the purpose of better understanding of the role of microRNA-203 in gene network of colorectal cancer may help exploit the whole potential of mir-203 in coloretal cancer.
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 12, p2394
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.12.049