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- Title
Unexpected Reaction of Ethyl 4-(Chloromethyl)pyrazolo-[5,1-c][1,2,4]triazine-3-carboxylates with Thiourea and Its Mechanism.
- Authors
Ledenyova, I. V.; Falaleev, A. V.; Shikhaliev, Kh. S.; Ryzhkova, E. A.; Zubkov, F. I.
- Abstract
The reaction of ethyl 4-(chloromethyl)pyrazolo[5,1-c][1,2,4]triazine-3-carboxylates with thiourea in dimethylformamide involves ANRORC rearrangement (Addition of the Nucleophile, Ring Opening, and Ring Closure) followed by N-formylation to give N-{5-(4-oxo-8-phenyl-1,4-dihydropyrazolo[5,1-c][1,2,4]- triazin-3-yl)-1,3-triazol-2-yl}formamides whose structure was confirmed by X-ray analysis. The reaction mechanism has been studied by HPLC/MS.
- Subjects
THIOUREA; FORMYLATION; NUCLEOPHILES; CHLOROMETHYL group; CHEMICAL formulas
- Publication
Russian Journal of General Chemistry, 2018, Vol 88, Issue 1, p73
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363218010115