We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Successful intervention for overwhelming postsplenectomy infection caused by non-vaccine pneumococcal serotype 23A.
- Authors
Kojima, Yuichi; Ikeda, Kazuna; Matsumura, Akihiro; Shimohama, Shun; Chang, Bin; Yoshida, Takayuki; Hamada, Kunio; Ito, Akihide; Ito, Toshiki
- Abstract
The spleen plays an important role in the body's immune defense against invasive infections, particularly those caused by encapsulated bacteria. Encapsulated bacterial infection in asplenic patients is a medical emergency called overwhelming postsplenectomy infection (OPSI) and has a mortality rate of 50–70%. Here, we report the case of a 51-year-old Asian man who complained of emesis and diarrhea as primary symptoms. He rapidly progressed to coma and was eventually diagnosed with OPSI (pyogenic ventriculitis/spondylitis) caused by non-vaccine pneumococcal serotype 23A. Aggressive management, including empiric antibiotic therapy, a staircase approach for intracranial pressure-targeted therapy and laminectomy/laminoplasty, resulted in a good recovery. Our report highlights that non-vaccine pneumococcal serotypes can cause disease in vaccinated patients.
- Subjects
COMA; SPONDYLITIS; EMERGENCY medicine; INFECTION; BACTERIAL diseases; SPLEEN; STAIRCASES
- Publication
Oxford Medical Case Reports, 2020, Vol 20, Issue 3, p1
- ISSN
2053-8855
- Publication type
Article
- DOI
10.1093/omcr/omaa018