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- Title
Association of Polymorphisms in X-Ray Repair Cross Complementing 1 Gene and Risk of Esophageal Squamous Cell Carcinoma in a Chinese Population.
- Authors
Yun, Yu-Xia; Dai, Li-Ping; Wang, Peng; Wang, Kai-Juan; Zhang, Jian-Ying; Xie, Wei
- Abstract
Objectives. To investigate the association between three single nucleotide polymorphisms (SNPs) in the X-ray repair cross complementing 1 gene (XRCC1) and the risk of esophageal squamous cell carcinoma (ESCC) in Chinese population. Methods. A case-control study including 381 primary ESCC patients recruited from hospital and 432 normal controls matched with patients by age and gender from Chinese Han population was conducted. The genotypes of three XRCC1 polymorphisms at −77T>C (T-77C), codon 194 (Arg194Trp), and codon 399 (Arg399Gln) were studied by means of polymerase chain reaction-restriction fragment length polymorphism techniques (PCR-RFLP). Unconditional logistic regression model and haplotype analysis were used to estimate associations of these three SNPs in XRCC1 gene with ESCC risk. Results. Polymorphisms at these three sites in XRCC1 gene were not found to be associated with risk for developing ESCC; however the haplotype Ccodon 194Gcodon 399C-77T>C was significantly associated with reduced risk of ESCC (OR: 0.62, 95% CI: 0.40–0.96) upon haplotype analysis. Conclusion. These results suggested that the gene-gene interactions might play vital roles in the progression on esophageal cancer in Chinese Han population and it would be necessary to confirm these findings in a large and multiethnic population.
- Subjects
CHINA; SQUAMOUS cell carcinoma; ESOPHAGEAL tumors; CHI-squared test; CONFIDENCE intervals; DNA; GENES; GENETIC polymorphisms; GOODNESS-of-fit tests; INTERVIEWING; QUESTIONNAIRES; RESEARCH funding; STATISTICAL sampling; LOGISTIC regression analysis; CASE-control method; DISEASE progression; DATA analysis software; HAPLOTYPES; ODDS ratio; GENOTYPES; TUMOR risk factors; CANCER risk factors
- Publication
BioMed Research International, 2015, Vol 2015, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2015/509215