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- Title
Integrin-linked Kinase is Essential for Environmental Enrichment Enhanced Hippocampal Neurogenesis and Memory.
- Authors
Xu, Xu-Feng; Li, Ting; Wang, Dong-Dong; Chen, Bing; Wang, Yue; Chen, Zhe-Yu
- Abstract
Environment enrichment (EE) has a variety of effects on brain structure and function. Brain-derived neurotrophic factor (BDNF) is essential for EE-induced hippocampal neurogenesis and memory enhancement. However, the intracellular pathway downstream of BDNF to modulate EE effects is poorly understood. Here we show that integrin-linked kinase (ILK) levels are elevated upon EE stimuli in a BDNF-dependent manner. Using ILK-shRNA (siILK) lentivirus, we demonstrate that knockdown of ILK impairs EE-promoted hippocampal neurogenesis and memory by increasing glycogen synthase kinase-3β (GSK3β) activity. Finally, overexpressing ILK in the hippocampus could rescue the neurogenesis and memory deficits in BDNF+/− mice. These results indicate that ILK is indispensable for BDNF-mediated hippocampal neurogenesis and memory enhancement upon EE stimuli via regulating GSK3β activity. This is a new insight of the precise mechanism in EE-enhanced memory processes and ILK is a potentially important therapeutic target that merits further study.
- Subjects
INTEGRINS; KINASES; DEVELOPMENTAL neurobiology; BRAIN-derived neurotrophic factor; HIPPOCAMPUS (Brain); LENTIVIRUSES
- Publication
Scientific Reports, 2015, p11456
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep11456