We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relationship of renin-angiotensin-aldosterone system polymorphisms and phenotypes to mortality in Chinese coronary atherosclerosis patients.
- Authors
En-Zhi Jia; Zhao-Hong Chen; Feng-Hui An; Li-Hua Li; Li-Li; Chang-Yan Guo; Yan Gu; Zhe Liu; Zhao-Yang Li; Tie-Bing Zhu; Lian-Sheng Wang; Chun-Jian Li; Xiang-Qing Kong; Wen-Zhu Ma; Zhi-Jian Yang
- Abstract
We performed a large, long-term cohort study to evaluate the association of renin-angiotensin-aldosterone system gene polymorphisms and baseline phenotypes to all-cause mortality among patients with angiographically confirmed coronary atherosclerosis. The study included 1075 subjects who underwent coronary angiography. Patients were genotyped for eight polymorphisms (rs4343, rs5186, rs5182, rs5049, rs5051, rs699, rs4762, and rs1799998), and their baseline plasma angiotensin II and aldosterone levels were measured. The interval between baseline and follow-up time-points ranged from 6.39 to 9.59 years. The results of multivariate regression analysis further indicated that high baseline angiotensin II levels (1.226 (1.024-1.468), p = 0.027) were independently associated with all-cause death. Therefore, we found that an increased baseline plasma angiotensin II level was associated with higher long-term all-cause mortality, even after correcting for established cardiovascular risk factors.
- Subjects
RENIN-angiotensin system; ATHEROSCLEROSIS; MORTALITY; ANGIOGRAPHY; ARTERIOGRAPHY; PATIENTS
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep04600