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- Title
Targeted Protein Degradation: Principles and Applications of the Proteasome.
- Authors
Kim, Yosup; Kim, Eun-Kyung; Chey, Yoona; Song, Min-Jeong; Jang, Ho Hee
- Abstract
The proteasome is a multi-catalytic protease complex that is involved in protein quality control via three proteolytic activities (i.e., caspase-, trypsin-, and chymotrypsin-like activities). Most cellular proteins are selectively degraded by the proteasome via ubiquitination. Moreover, the ubiquitin–proteasome system is a critical process for maintaining protein homeostasis. Here, we briefly summarize the structure of the proteasome, its regulatory mechanisms, proteins that regulate proteasome activity, and alterations to proteasome activity found in diverse diseases, chemoresistant cells, and cancer stem cells. Finally, we describe potential therapeutic modalities that use the ubiquitin–proteasome system.
- Subjects
PROTEOLYSIS; PROTEASOMES; CANCER stem cells; TRYPSIN
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 14, p1846
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12141846