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- Title
Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study.
- Authors
Buell-Acosta, Julieth Daniela; Garces, Maria Fernanda; Parada-Baños, Arturo José; Angel-Muller, Edith; Paez, Maria Carolina; Eslava-Schmalbach, Javier; Escobar-Cordoba, Franklin; Caminos-Cepeda, Sofia Alexandra; Lacunza, Ezequiel; Castaño, Justo P.; Nogueiras, Rubén; Dieguez, Carlos; Ruiz-Parra, Ariel Iván; Caminos, Jorge Eduardo
- Abstract
(1) Background: Fibroblast growth factor 21 (FGF-21) is an endocrine factor involved in glucose and lipid metabolism that exerts pleiotropic effects. The aim of this study was to investigate the serum FGF-21 profile in healthy and mild preeclamptic pregnant women at each trimester of pregnancy; (2) Methods: Serum FGF-21 levels were determined by ELISA in a nested case-control study within a longitudinal cohort study that included healthy (n = 54) and mild preeclamptic (n = 20) pregnant women, women at three months after delivery (n = 20) and eumenorrheic women during the menstrual cycle (n = 20); (3) Results: FGF-21 levels were significantly lower in the mid-luteal phase compared to the early follicular phase of the menstrual cycle in eumenorrheic women (p < 0.01). Maternal levels of FGF-21 were significantly lower in the first and second trimesters and peaked during the third trimester in healthy pregnant women (p < 0.01). Serum levels of FGF-21 in healthy pregnant were significantly lower in the first and second trimester of pregnancy compared with the follicular phase of the menstrual cycle and postpartum (p < 0.01). Serum FGF-21 levels were significantly higher in preeclamptic compared to healthy pregnant women during pregnancy (p < 0.01); (4) Conclusions: These results suggest that a peak of FGF-21 towards the end of pregnancy in healthy pregnancy and higher levels in preeclamptic women might play a critical role that contributes to protecting against the negatives effects of high concentrations of non-esterified fatty acids (NEFA) and hypertensive disorder. Furthermore, FGF-21 might play an important role in reproductive function in healthy eumenorrheic women during the menstrual cycle.
- Subjects
MENSTRUAL cycle; FIBROBLAST growth factors; PREGNANT women; PREECLAMPSIA; PREGNANCY; SECOND trimester of pregnancy
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 14, pN.PAG
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11142251