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Inhibition of Cdk2 kinase activity selectively targets the CD44<sup>+</sup>/CD24<sup>-/Low</sup> stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells.
- Published in:
- International Journal of Oncology, 2014, v. 45, n. 3, p. 1193, doi. 10.3892/ijo.2014.2523
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- Publication type:
- Article
Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia.
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- International Journal of Oncology, 2014, v. 45, n. 3, p. 909, doi. 10.3892/ijo.2014.2525
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- Publication type:
- Article
Emerging targeted therapies for melanoma treatment (Review).
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- International Journal of Oncology, 2014, v. 45, n. 2, p. 516, doi. 10.3892/ijo.2014.2481
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- Publication type:
- Article
Phytol and Heptacosane Are Possible Tools to Overcome Multidrug Resistance in an In Vitro Model of Acute Myeloid Leukemia.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 3, p. 356, doi. 10.3390/ph15030356
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- Article
Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell.
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- Pharmaceuticals (14248247), 2019, v. 12, n. 3, p. 124, doi. 10.3390/ph12030124
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- Publication type:
- Article
Understanding the Roles of the Hedgehog Signaling Pathway during T-Cell Lymphopoiesis and in T-Cell Acute Lymphoblastic Leukemia (T-ALL).
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- International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 2962, doi. 10.3390/ijms24032962
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- Publication type:
- Article
Subcellular Localization Relevance and Cancer-Associated Mechanisms of Diacylglycerol Kinases.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 15, p. 5297, doi. 10.3390/ijms21155297
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- Article
Clusterin enhances AKT2‐mediated motility of normal and cancer prostate cells through a PTEN and PHLPP1 circuit.
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- Journal of Cellular Physiology, 2019, v. 234, n. 7, p. 11188, doi. 10.1002/jcp.27768
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- Publication type:
- Article
Targeting the phosphatidylinositol 3‐kinase/Akt/mechanistic target of rapamycin signaling pathway in B‐lineage acute lymphoblastic leukemia: An update.
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- Journal of Cellular Physiology, 2018, v. 233, n. 10, p. 6440, doi. 10.1002/jcp.26539
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- Publication type:
- Article
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.
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- Scientific Reports, 2017, p. 43013, doi. 10.1038/srep43013
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- Article
Bevacizumab in the treatment of NSCLC: patient selection and perspectives.
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- Lung Cancer: Targets & Therapy, 2017, v. 8, p. 259, doi. 10.2147/LCTT.S110306
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- Publication type:
- Article
A miRNA screening identifies miR-192-5p as associated with response to azacitidine and lenalidomide therapy in myelodysplastic syndromes.
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- Clinical Epigenetics, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13148-023-01441-9
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- Publication type:
- Article
Aurora-A Mitotic Kinase Induces Endocrine Resistance through Down-Regulation of ERα Expression in Initially ERα+ Breast Cancer Cells.
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- PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0096995
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- Publication type:
- Article
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells.
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- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0065569
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- Publication type:
- Article
Signaling through 3',5'-Cyclic Adenosine Monophosphate and Phosphoinositide-3 Kinase Induces Sodium/Iodide Symporter Expression in Breast Cancer.
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- Journal of Clinical Endocrinology & Metabolism, 2004, v. 89, n. 10, p. 5196, doi. 10.1210/jc.2004-0907
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- Article
Models of Anergy in the Human Jurkat T Cell Line.
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- Assay & Drug Development Technologies, 2003, v. 1, n. 4, p. 537
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- Publication type:
- Article
The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms.
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- Journal of Molecular Medicine, 2012, v. 90, n. 6, p. 667, doi. 10.1007/s00109-011-0844-1
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- Publication type:
- Article
Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for 'vertical' and 'lateral' combination strategies.
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- Journal of Molecular Medicine, 2012, v. 90, n. 10, p. 1133, doi. 10.1007/s00109-012-0886-z
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- Publication type:
- Article
Transfer of specificity by murine α and β T-cell receptor genes.
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- Nature, 1986, v. 320, n. 6059, p. 232, doi. 10.1038/320232a0
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- Article
Phospholipases in Gliomas: Current Knowledge and Future Perspectives from Bench to Bedside.
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- Biomolecules (2218-273X), 2023, v. 13, n. 5, p. 798, doi. 10.3390/biom13050798
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- Publication type:
- Article
APR-246—The Mutant TP53 Reactivator—Increases the Effectiveness of Berberine and Modified Berberines to Inhibit the Proliferation of Pancreatic Cancer Cells.
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- Biomolecules (2218-273X), 2022, v. 12, n. 2, p. 276, doi. 10.3390/biom12020276
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- Publication type:
- Article
The therapeutic potential of mTOR inhibitors in breast cancer.
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- British Journal of Clinical Pharmacology, 2016, v. 82, n. 5, p. 1189, doi. 10.1111/bcp.12958
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- Publication type:
- Article
Potential use of rapamycin in HIV infection M. Donia et al. Rapamycin for HIV treatment.
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- British Journal of Clinical Pharmacology, 2010, v. 70, n. 6, p. 784, doi. 10.1111/j.1365-2125.2010.03735.x
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- Publication type:
- Article
Integrin signaling links protein kinase C?to the protein kinase B/Akt survival pathway in recurrent prostate cancer cells.
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- Oncogene, 2004, v. 23, n. 53, p. 8659, doi. 10.1038/sj.onc.1207900
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- Publication type:
- Article
Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.
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- Oncogene, 2004, v. 23, n. 47, p. 7810, doi. 10.1038/sj.onc.1208055
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- Publication type:
- Article
Raf promotes human herpesvirus-8 (HHV-8/KSHV) infection.
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- Oncogene, 2004, v. 23, n. 30, p. 5227, doi. 10.1038/sj.onc.1207643
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- Publication type:
- Article
Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.
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- Oncogene, 2003, v. 22, n. 16, p. 2478, doi. 10.1038/sj.onc.1206321
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- Publication type:
- Article
P21<sup>Cip1</sup> induced by Raf is associated with increased Cdk4 activity in hematopoietic cells.
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- Oncogene, 2001, v. 20, n. 32, p. 4354, doi. 10.1038/sj.onc.1204564
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- Publication type:
- Article
The Unfolded Protein Response: A Novel Therapeutic Target in Acute Leukemias.
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- Cancers, 2020, v. 12, n. 2, p. 333, doi. 10.3390/cancers12020333
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- Publication type:
- Article
The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic Response.
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- Cancers, 2019, v. 11, n. 5, p. 629, doi. 10.3390/cancers11050629
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- Publication type:
- Article
The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology.
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- Cancers, 2010, v. 2, n. 3, p. 1576, doi. 10.3390/cancers2031576
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- Article
NOTCH3 expression is linked to breast cancer seeding and distant metastasis.
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- 2018
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- Publication type:
- journal article
Identification of SLC22A17 DNA methylation hotspot as a potential biomarker in cutaneous melanoma.
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- Journal of Translational Medicine, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12967-024-05622-9
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- Publication type:
- Article
A conditionally-active form of MEK1 results in autocrine transformation of human and mouse hematopoietic cells.
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- Oncogene, 2000, v. 19, n. 4, p. 526, doi. 10.1038/sj.onc.1203337
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- Publication type:
- Article
Phospholipase C beta1 (PI‐PLCbeta1)/Cyclin D3/protein kinase C (PKC) alpha signaling modulation during iron‐induced oxidative stress in myelodysplastic syndromes (MDS).
- Published in:
- FASEB Journal, 2020, v. 34, n. 11, p. 15400, doi. 10.1096/fj.202000933RR
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- Publication type:
- Article
Nuclear translocation of PKC-α is associated with cell cycle arrest and erythroid differentiation in myelodysplastic syndromes (MDSs).
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- FASEB Journal, 2018, v. 32, n. 2, p. 681, doi. 10.1096/fj.201700690R
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- Publication type:
- Article
Nuclear Inositide Signaling Via Phospholipase C.
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- Journal of Cellular Biochemistry, 2017, v. 118, n. 8, p. 1969, doi. 10.1002/jcb.25894
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- Publication type:
- Article
Colon Cancer Cells Gene Expression Signature As Response to 5- Fluorouracil, Oxaliplatin, and Folinic Acid Treatment.
- Published in:
- Frontiers in Pharmacology, 2016, p. 1, doi. 10.3389/fphar.2016.00172
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- Publication type:
- Article
Expression of multidrug resistance proteins in prostate cancer is related with cell sensitivity to chemotherapeutic drugs.
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- Prostate, 2009, v. 69, n. 13, p. 1448, doi. 10.1002/pros.20991
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- Publication type:
- Article
Analysis of TIMP-1 Gene Polymorphisms in Italian Sclerodermic Patients.
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- Journal of Clinical Laboratory Analysis, 2006, v. 20, n. 5, p. 173, doi. 10.1002/jcla.20128
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- Publication type:
- Article
Comparative Study of Rapamycin and Temsirolimus Demonstrates Superimposable Anti-Tumour Potency on Prostate Cancer Cells.
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- Basic & Clinical Pharmacology & Toxicology, 2013, v. 112, n. 1, p. 63, doi. 10.1111/j.1742-7843.2012.00923.x
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- Publication type:
- Article
Recent Progress in Discovering the Role of Carotenoids and Their Metabolites in Prostatic Physiology and Pathology with a Focus on Prostate Cancer—A Review—Part I: Molecular Mechanisms of Carotenoid Action.
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- Antioxidants, 2021, v. 10, n. 4, p. 585, doi. 10.3390/antiox10040585
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- Publication type:
- Article
Recent Progress in Discovering the Role of Carotenoids and Metabolites in Prostatic Physiology and Pathology—A Review—Part II: Carotenoids in the Human Studies.
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- Antioxidants, 2021, v. 10, n. 2, p. 319, doi. 10.3390/antiox10020319
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- Publication type:
- Article
Cutaneous melanoma: From pathogenesis to therapy (Review).
- Published in:
- International Journal of Oncology, 2018, v. 52, n. 4, p. 1071, doi. 10.3892/ijo.2018.4287
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- Publication type:
- Article
Oleocanthal exerts antitumor effects on human liver and colon cancer cells through ROS generation.
- Published in:
- International Journal of Oncology, 2017, v. 51, n. 2, p. 433, doi. 10.3892/ijo.2017.4049
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- Publication type:
- Article
Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma.
- Published in:
- International Journal of Cancer, 2019, v. 144, n. 10, p. 2613, doi. 10.1002/ijc.31963
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- Publication type:
- Article
HIV-protease inhibitors for the treatment of cancer: Repositioning HIV protease inhibitors while developing more potent NO-hybridized derivatives?
- Published in:
- International Journal of Cancer, 2017, v. 140, n. 8, p. 1713, doi. 10.1002/ijc.30529
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- Publication type:
- Article
Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer.
- Published in:
- PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0152104
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- Publication type:
- Article
Nuclear Phosphatidylinositol Signaling: Focus on Phosphatidylinositol Phosphate Kinases and Phospholipases C.
- Published in:
- Journal of Cellular Physiology, 2016, v. 231, n. 8, p. 1645, doi. 10.1002/jcp.25273
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- Publication type:
- Article
Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways.
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- Journal of Cellular Physiology, 2011, v. 226, n. 11, p. 2762, doi. 10.1002/jcp.22647
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- Article