We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lipoprotein(a) predicts a new onset of chronic kidney disease in people with Type 2 diabetes mellitus.
- Authors
Yun, J.‐S.; Ahn, Y.‐B.; Song, K.‐H.; Yoo, K.‐D.; Park, Y.‐M.; Kim, H.‐W.; Ko, S.‐H.
- Abstract
Aims We investigated the association between lipoprotein(a) [Lp(a)] level and new-onset chronic kidney disease ( CKD) in patients with Type 2 diabetes. Methods We conducted a prospective cohort study from March 2003 to December 2004 with a median follow-up time of 10.1 years. Patients aged 25-75 years with Type 2 diabetes and without CKD [estimated glomerular filtration rate ( eGFR) ≥ 90 ml/min/1.73 m2) were consecutively enrolled. The eGFR was measured at least twice every year , and new-onset CKD was defined as a decreased eGFR status of < 60 ml/min/1.73 m2 using a Chronic Kidney Disease Epidemiology Collaboration ( CKD- EPI) equation. Results Of the 862 patients who were enrolled, 560 (65.0%) completed the follow-up and 125 (22.3%) progressed to CKD. The mean age and duration of diabetes were 53.3 ± 9.6 and 7.5 ± 6.0 years, respectively. The baseline eGFR was 101.8 ± 11.3 ml/min/1.73 m2. After adjusting for multiple confounding factors, a Cox hazard regression analysis revealed that the third tertile of Lp(a) was significantly associated with the development of CKD during the observation period when compared with the first tertile [hazard ratio 2.12 (95% confidence interval 1.33-3.36); P = 0.001). Conclusions In this prospective, longitudinal, observational cohort study, we demonstrated that the Lp(a) level was an independent prognostic factor for the future development of CKD in patients with Type 2 diabetes.
- Subjects
CARDIOVASCULAR disease diagnosis; KIDNEY disease diagnosis; CHRONIC kidney failure; NEPHROTIC syndrome diagnosis; TYPE 2 diabetes complications; AGE factors in disease; ACE inhibitors; CHOLESTEROL; PEOPLE with diabetes; FENOFIBRATE; GLOMERULAR filtration rate; GLYCOSYLATED hemoglobin; HIGH density lipoproteins; HIGH performance liquid chromatography; PATIENT aftercare; INSULIN; LIPOPROTEINS; LONGITUDINAL method; LOW density lipoproteins; TYPE 2 diabetes; STATINS (Cardiovascular agents); DATA analysis; BODY mass index; ACQUISITION of data; PROPORTIONAL hazards models; PATIENT selection; DESCRIPTIVE statistics; MANN Whitney U Test; DIAGNOSIS; DISEASE risk factors
- Publication
Diabetic Medicine, 2016, Vol 33, Issue 5, p639
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/dme.12862