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- Title
Insulin/Insulin-Like Growth Factor Signaling Controls Non-Dauer Developmental Speed in the Nematode Caenorhabditis elegans.
- Authors
Ruaud, Anne-Françoise; Katic, Iskra; Bessereau, Jean-Louis
- Abstract
Identified as a major pathway controlling entry in the facultative dauer diapause stage, the DAF-2/ Insulin receptor (InsR) signaling acts in multiple developmental and physiological regulation events in Caenorhabditis elegans. Here we identified a role of the insulin-like pathway in controlling developmental speed during the C. elegans second larval stage. This role relies on the canonical DAF-16/FOXO-dependent branch of the insulin-like signaling and is largely independent of dauer formation. Our studies provide further evidence for broad conservation of insulin/insulin-like growth factor (IGF) functions in developmental speed control.
- Subjects
SOMATOMEDIN; CAENORHABDITIS elegans; INSULIN; NEMATODES; GROWTH
- Publication
Genetics, 2011, Vol 187, Issue 1, p337
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.110.123323