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- Title
Histological changes in endocrine and exocrine pancreatic tissue from patients exposed to incretin-based therapies.
- Authors
Ueberberg, Sandra; Jütte, Hendrik; Uhl, Waldemar; Schmidt, Wolfgang; Nauck, Michael; Montanya, Eduard; Tannapfel, Andrea; Meier, Juris
- Abstract
Aims Incretin-based therapies have been associated with an increased risk of pancreatitis. Recently, various histological abnormalities have been reported in human pancreatic tissue from brain-dead organ donors who had been exposed to incretin-based drugs. In the present study we examined pancreatic tissue collected at surgery. Methods Human pancreatic tissue from 7 type 2-diabetic patients treated with incretin-based drugs (type 2-I), 6 diabetic patients without incretin treatment (type 2- NI), 11 patients without diabetes (no diabetes group) and 9 brain-dead organ donors ( BDOD group) was examined. Results Fractional beta-cell area was reduced in the type 2- NI group compared to the group without diabetes ( P < .05), but there was no difference compared to the type 2-I patients. Alpha-cell area ( P = .30), beta-cell replication ( P = .17) and alpha-cell replication ( P = .91) were not different. There were also no differences in acinar cell ( P = .13) and duct cell replication ( P = .099). Insulin-positive duct cells were more frequent in the type 2-I and the BDOD groups ( P = .034). No co-expression of insulin and glucagon was detected. Pancreatic intraepithelial neoplasia ( PanIN) lesions were very rare, all low-grade ( PanIN 1a and 1b) and tended to occur more frequently in the type 2-I group ( P = .084). Conclusions The present results did not reveal marked histological abnormalities in the pancreas of incretin-treated patients with type 2 diabetes. Low numbers of specimens available and a large inter-individual variability of the findings warrant caution regarding the interpretation of histological data concerning drug effects on the human pancreas.
- Subjects
INCRETINS; PANCREATITIS; PHARMACODYNAMICS; PANCREAS; DIGESTIVE organs; DISEASE risk factors
- Publication
Diabetes, Obesity & Metabolism, 2016, Vol 18, Issue 12, p1253
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.12766