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- Title
Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate.
- Authors
Oliveira, Luiz Filipe Gonçalves; Souza-Silva, Franklin; Cysne-Finkelstein, Léa; Rabelo, Kíssila; Amorim, Juliana Fernandes; Azevedo, Adriana de Souza; Bourguignon, Saulo Cabral; Ferreira, Vitor Francisco; Paes, Marciano Viana; Alves, Carlos Roberto
- Abstract
Leishmaniasis remains a serious public health problem in developing countries without effective control, whether by vaccination or chemotherapy. Part of the failure of leishmaniasis control is due to the lack of new less toxic and more effective drugs able to eliminate both the lesions and the parasite. Oxiranes derived from naphthoquinones now being assayed are promising drugs for the treatment of this group of diseases. The predicted pharmacokinetic properties and toxicological profiles of epoxy-α-lapachone and epoxymethoxy-lawsone have now been compared to those of meglumine antimoniate, and histological changes induced by these drugs in noninfected BALB/c mice tissues are described. Effects of these compounds on liver, kidney, lung, heart, and cerebral tissues of healthy mice were examined. The data presented show that both these oxiranes and meglumine antimoniate induce changes in all BALB/c mice tissues, with the lung, heart, and brain being the most affected. Epoxymethoxy-lawsone was the most toxic to lung tissue, while most severe damage was caused in the heart by epoxy-α-lapachone. Meglumine antimoniate caused mild-to-moderate changes in heart and lung tissues.
- Subjects
THERAPEUTIC use of antimony; LUNG diseases; LEISHMANIASIS treatment; LEISHMANIASIS diagnosis; ANIMAL experimentation; ANTIMONY; DEVELOPING countries; CLINICAL drug trials; DRUG toxicity; ETHYL chloride; HEART diseases; LEISHMANIASIS; MICE; PARASITIC diseases; PUBLIC health; RESEARCH funding; TREATMENT duration; DATA analysis software; DISEASE complications; DISEASE risk factors
- Publication
BioMed Research International, 2017, Vol 2017, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2017/9840210