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- Title
The alpha1L-adrenoceptor is an alternative phenotype of the alpha1A-adrenoceptor.
- Authors
Nelson, C. P.; Nelson, Cp
- Abstract
Despite over two decades of research, the molecular identity of the alpha1L-adrenoceptor phenotype has remained elusive. In this issue of the BJP, Gray et al. (2008) provide persuasive evidence that the in vivo alpha1L-adrenoceptor phenotype requires the expression of the alpha1A-adrenoceptor gene. They have shown that in mice lacking the functional alpha1A-adrenoceptor gene, alpha1L-mediated responses to noradrenaline in prostate smooth muscle are substantially attenuated. These findings support earlier evidence that the alpha(1L)-adrenoceptor profile represents a functional phenotype of the alpha(1A)-adrenoceptor gene product, but additional cell background-dependent factors must act in concert with the alpha(1A)-adrenoceptor protein to determine whether an alpha(1L)- or a classical alpha(1A)-adrenoceptor profile is expressed. The challenge remains to establish the nature of these cellular factors and the mechanism(s) by which they influence G-protein-coupled receptor pharmacology.
- Subjects
ADRENERGIC receptors; SMOOTH muscle; PHARMACEUTICAL research; MALE reproductive organs; PHENOTYPES; MEDICAL research
- Publication
British Journal of Pharmacology, 2008, Vol 155, Issue 1, p1
- ISSN
0007-1188
- Publication type
journal article
- DOI
10.1038/bjp.2008.264