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- Title
Presymptomatic MS or radiologically isolated syndrome should be actively monitored and treated: Commentary.
- Authors
Inglese, Matilde; Amato, Maria Pia
- Abstract
In the 2017 diagnostic criteria for MS, a first clinical attack is still required to make the diagnosis of MS. The evidence that the biological onset of multiple sclerosis (MS) can anticipate the clinical onset by several years has led to an ever-growing number of studies aimed at characterizing and monitoring the preclinical phase of MS.[1] Individuals with incidental brain or spinal cord lesions highly suggestive of central nervous system (CNS) demyelination without related symptoms and signs are classified as having a radiologically isolated syndrome (RIS).[2] These individuals have a 34% risk of conversion to MS over 5 years[3] and a 51% risk over 10 years[4] especially if they are young, with infratentorial or spinal cord lesions, with cerebrospinal fluid (CSF)-restricted oligoclonal bands, and development of new gadolinium-enhancing lesions on follow-up magnetic resonance imaging (MRI) scans.
- Subjects
SYNDROMES; MULTIPLE sclerosis; SYMPTOMS; PROGNOSIS
- Publication
Multiple Sclerosis Journal, 2023, Vol 29, Issue 7, p797
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/13524585231172941