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- Title
Detection of Propionibacterium acnes in cutaneous lichenoid sarcoidosis in a patient with Blau syndrome.
- Authors
Yamamoto, Toshiyuki; Miura, Keiko; Eishi, Yoshinobu
- Abstract
Blau syndrome is a rare autosomal dominant genodermatosis caused by mutations in the NOD2 (also known as CARD15) and is clinically characterized by idiopathic granulomatous inflammation of multiple organs, mainly the skin, eyes, and joints.[[1]] Cutaneous manifestations of Blau syndrome are discrete, small lichenoid papules or ichthyosiform eruptions on the extremities and trunk.[[2], [4]] Histopathology typically reveals non-caseating epithelioid cell granulomas in the dermis, and thus Blau syndrome is considered to overlap with early-onset sarcoidosis. The present case is the second of I P. acnes i detected in the lesional skin of Blau syndrome; however, there are a few points that should be clarified, that is, whether I P. acnes i is distributed through the disseminated papular lesions or the route of I P. acnes i invasion in juvenile-onset sarcoidosis, and further studies are necessary. They speculated that the mechanism of sarcoid granuloma formation in Blau syndrome may be the result of NOD2 hyperactivity in the presence of MDP, which is a component of I P. acnes i .
- Subjects
SARCOIDOSIS; CUTIBACTERIUM acnes; SYNDROMES
- Publication
International Journal of Dermatology, 2023, Vol 62, Issue 6, pe353
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/ijd.16583