We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tuft Cells: Detectors, Amplifiers, Effectors and Targets in Parasite Infection.
- Authors
Campillo Poveda, Marta; Britton, Collette; Devaney, Eileen; McNeilly, Tom N.; Gerbe, François; Jay, Philippe; Maizels, Rick M.
- Abstract
Tuft cells have recently emerged as the focus of intense interest following the discovery of their chemosensory role in the intestinal tract, and their ability to activate Type 2 immune responses to helminth parasites. Moreover, they populate a wide range of mucosal tissues and are intimately connected to immune and neuronal cells, either directly or through the release of pharmacologically active mediators. They are now recognised to fulfil both homeostatic roles, in metabolism and tissue integrity, as well as acting as the first sensors of parasite infection, immunity to which is lost in their absence. In this review we focus primarily on the importance of tuft cells in the intestinal niche, but also link to their more generalised physiological role and discuss their potential as targets for the treatment of gastrointestinal disorders.
- Subjects
MUCOUS membranes; HELMINTHS; TISSUE metabolism; DETECTORS; IMMUNE response; PARASITES
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 20, p2477
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12202477