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- Title
An Overview on the N-Heterocyclic Carbene-Catalyzed Aza-Benzoin Condensation Reaction.
- Authors
Albanese, Domenico C. M.; Gaggero, Nicoletta
- Abstract
The <italic>N</italic>-heterocyclic carbene(NHCs)-catalyzed aza-benzoin condensation reaction is an efficient, single step strategy which employs easily available substrates, such as aldehydes and imines, to provide α-amino ketones. The multifunctionality and high reactivity of α-amino ketones makes these structures attractive for medicinal chemistry and as precursors of a variety of amine derivatives. The different electrophilic characteristics of aldehydes and imines ensure a high regioselective reaction. Enantiomerically-enriched α-amino ketones have been synthesized through stereoselective couplings promoted by chiral <italic>N</italic>-heterocyclic carbenes. One-pot domino procedures, including an aza-benzoin step, allow valuable complex molecules to be accessed.
- Subjects
HETEROCYCLIC chemistry; CARBENE derivatives; BENZOIN derivatives; CONDENSATION reactions; AMINO ketones
- Publication
Catalysts (2073-4344), 2018, Vol 8, Issue 5, p181
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal8050181