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- Title
Cost-Effectiveness Analysis of Capecitabine Compared with Bolus 5-Fluorouracil/l-Leucovorin for the Adjuvant Treatment of Colon Cancer in Japan.
- Authors
Shiroiwa, Takeru; Fukuda, Takashi; Shimozuma, Kojiro; Ohashi, Yasuo; Tsutani, Kiichiro
- Abstract
Objective: A cost-effectiveness analysis of oral capecitabine versus intravenous bolus 5-fluorouracil/l-leucovorin (FU/LV) as adjuvant therapy in patients with stage 3 colon cancer was performed from a Japanese healthcare payer perspective. Methods: Adjuvant therapy comprised 24 weeks of treatment with either oral capecitabine 1250 mg/m² twice daily on days 1-14 of a 21-day cycle or intravenous bolus FU 500mg/m² and LV 250mg/m² weekly for 6 weeks of an 8-week cycle (Roswell Park regimen). The analysis comprised short-term (1 year after initiation of adjuvant therapy) and long-term (up to 15 years) components. The long-term analysis involved a three-state (disease-free, recurrence and death) Markov model. Estimates for transition probabilities, costs and utilities were derived from the X-ACT trial, a Japanese phase II trial, and other published sources. Cost estimates were considered from the perspective of a healthcare payer. Costs were expressed in Japanese Yen (f), year 2007 values. A discount rate of 3% was applied to costs and outcomes. Cost effectiveness was expressed as a cost per QALY. The effects of uncertainty were explored through one-way and probabilistic sensitivity analyses. Results: In the 1-year analysis, direct costs were f440 000 ($US4000) less per patient with capecitabine than with FU/LV. In the long-term analysis, differences between treatments in direct medical costs ranged from f470 000 ($US4300) to f580 000 ($US5300) depending on the time horizon used. Capecitabine was also projected to increase the number of QALYs compared with FU/LV. The sensitivity analysis suggested that the model outcome was robust. The probabilistic sensitivity analysis estimate of capecitabine being the dominant regimen was 96.6% at a zero willingness to pay. Direct costs remained lower with capecitabine if the price of generic LV was ⩾50% of the branded product. Conclusion: This analysis suggests that capecitabine improves health outcomes and lowers direct costs compared with bolus FU/LV (i.e. dominant treatment strategy) when used as adjuvant therapy in patients with stage 3 colon cancer in Japan.
- Subjects
JAPAN; COST effectiveness; COLON cancer; MEDICAL care costs; ADJUVANT treatment of cancer
- Publication
PharmacoEconomics, 2009, Vol 27, Issue 7, p597
- ISSN
1170-7690
- Publication type
Article
- DOI
10.2165/11310110-000000000-00000