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- Title
Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; Results from the European prospective investigation into cancer and nutrition.
- Authors
Cust, Anne E.; Allen, Naomi E.; Rinaldi, Sabina; Dossus, Laure; Friedenreich, Christine; Olsen, Anja; Tjønneland, Anne; Overvad, Kim; Clavel-Chapelon, Françoise; Boutron-Ruault, Marie-Christine; Linseisen, Jakob; Chang-Claude, Jenny; Boeing, Heiner; Schulz, Mandy; Benetou, Vassiliki; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Palli, Domenico; Berrino, Franco; Tumino, Rosario
- Abstract
We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition, to examine the associations between prediagnostic serum concentrations of C-peptide, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-2, and endometrial cancer risk. Among pre- and post-menopausal women, who were not currently using exogenous hormones, 286 women developed incident endometrial cancer during an average 5.1 years follow-up. Using risk set sampling, 555 matched control subjects were selected. In conditional logistic regression models adjusted for matching factors only, endometrial cancer risk increased with increasing serum levels of C-peptide (relative risks (RR) for the top vs. bottom quartile = 2.13 [95% confidence interval (CI) 1.33-3.41], p
- Publication
International Journal of Cancer, 2007, Vol 120, Issue 12, p2656
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.22578