OpenURL Connection Search

Select item for more details and to access through your institution.

PTP61F Mediates Cell Competition and Mitigates Tumorigenesis.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 23, p. 12732, doi. 10.3390/ijms222312732
By:
- La Marca, John E.;
- Willoughby, Lee F.;
- Allan, Kirsten;
- Portela, Marta;
- Goh, Pei Kee;
- Tiganis, Tony;
- Richardson, Helena E.
Publication type:
Article
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
Published in:
2011
By:
- Wiede, Florian;
- Shields, Benjamin J.;
- Chew, Sock Hui;
- Kyparissoudis, Konstantinos;
- van Vliet, Catherine;
- Galic, Sandra;
- Tremblay, Michel L.;
- Russell, Sarah M.;
- Godfrey, Dale I.;
- Tiganis, Tony
Publication type:
journal article
Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.
Published in:
EMBO Reports, 2009, v. 10, n. 5, p. 487, doi. 10.1038/embor.2009.28
By:
- Ivetac, Ivan;
- Gurung, Rajendra;
- Hakim, Sandra;
- Horan, Kristy A;
- Sheffield, David A;
- Binge, Lauren C;
- Majerus, Philip W;
- Tiganis, Tony;
- Mitchell, Christina A
Publication type:
Article
Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice.
Published in:
Neuroendocrinology, 2019, v. 109, n. 4, p. 374, doi. 10.1159/000500201
By:
- Balland, Eglantine;
- Chen, Weiyi;
- Tiganis, Tony;
- Cowley, Michael A.
Publication type:
Article
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAF<sup>V600</sup> melanoma.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28705-x
By:
- Smith, Lorey K.;
- Parmenter, Tiffany;
- Kleinschmidt, Margarete;
- Kusnadi, Eric P.;
- Kang, Jian;
- Martin, Claire A.;
- Lau, Peter;
- Patel, Riyaben;
- Lorent, Julie;
- Papadopoli, David;
- Trigos, Anna;
- Ward, Teresa;
- Rao, Aparna D.;
- Lelliott, Emily J.;
- Sheppard, Karen E.;
- Goode, David;
- Hicks, Rodney J.;
- Tiganis, Tony;
- Simpson, Kaylene J.;
- Larsson, Ola
Publication type:
Article
PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours.
Published in:
EMBO Journal, 2020, v. 39, n. 2, p. N.PAG, doi. 10.15252/embj.2019103637
By:
- Wiede, Florian;
- Lu, Kun‐Hui;
- Du, Xin;
- Liang, Shuwei;
- Hochheiser, Katharina;
- Dodd, Garron T;
- Goh, Pei K;
- Kearney, Conor;
- Meyran, Deborah;
- Beavis, Paul A;
- Henderson, Melissa A;
- Park, Simone L;
- Waithman, Jason;
- Zhang, Sheng;
- Zhang, Zhong‐Yin;
- Oliaro, Jane;
- Gebhardt, Thomas;
- Darcy, Phillip K;
- Tiganis, Tony
Publication type:
Article
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice.
Published in:
2024
By:
- Xi, Yannan;
- Liu, Siming;
- Bettaieb, Ahmed;
- Matsuo, Kosuke;
- Matsuo, Izumi;
- Hosein, Ellen;
- Chahed, Samah;
- Wiede, Florian;
- Zhang, Sheng;
- Zhang, Zhong-Yin;
- Kulkarni, Rohit N.;
- Tiganis, Tony;
- Haj, Fawaz G.
Publication type:
Correction Notice
Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.
Published in:
Diabetologia, 2016, v. 59, n. 12, p. 2632, doi. 10.1007/s00125-016-4084-3
By:
- Merry, Troy;
- Tran, Melanie;
- Dodd, Garron;
- Mangiafico, Salvatore;
- Wiede, Florian;
- Kaur, Supreet;
- McLean, Catriona;
- Andrikopoulos, Sofianos;
- Tiganis, Tony
Publication type:
Article
Erratum to: Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.
Published in:
2016
By:
- Merry, Troy;
- Tran, Melanie;
- Dodd, Garron;
- Mangiafico, Salvatore;
- Wiede, Florian;
- Kaur, Supreet;
- McLean, Catriona;
- Andrikopoulos, Sofianos;
- Tiganis, Tony
Publication type:
Erratum
Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice.
Published in:
Diabetologia, 2015, v. 58, n. 1, p. 122, doi. 10.1007/s00125-014-3413-7
By:
- Xi, Yannan;
- Liu, Siming;
- Bettaieb, Ahmed;
- Matsuo, Kosuke;
- Matsuo, Izumi;
- Hosein, Ellen;
- Chahed, Samah;
- Wiede, Florian;
- Zhang, Sheng;
- Zhang, Zhong-Yin;
- Kulkarni, Rohit;
- Tiganis, Tony;
- Haj, Fawaz
Publication type:
Article
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41145-5
By:
- Qiu, Bin;
- Lawan, Ahmed;
- Xirouchaki, Chrysovalantou E.;
- Yi, Jae-Sung;
- Robert, Marie;
- Zhang, Lei;
- Brown, Wendy;
- Fernández-Hernando, Carlos;
- Yang, Xiaoyong;
- Tiganis, Tony;
- Bennett, Anton M.
Publication type:
Article
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40170-8
By:
- Liang, Shuwei;
- Tran, Eric;
- Du, Xin;
- Dong, Jiajun;
- Sudholz, Harrison;
- Chen, Hao;
- Qu, Zihan;
- Huntington, Nicholas D.;
- Babon, Jeffrey J.;
- Kershaw, Nadia J.;
- Zhang, Zhong-Yin;
- Baell, Jonathan B.;
- Wiede, Florian;
- Tiganis, Tony
Publication type:
Article
Strain-Dependent Differences in Bone Development, Myeloid Hyperplasia, Morbidity and Mortality in Ptpn2-Deficient Mice.
Published in:
PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0036703
By:
- Wiede, Florian;
- Sock Hui Chew;
- van Vliet, Catherine;
- Poulton, Ingrid J.;
- Kyparissoudis, Konstantinos;
- Sasmono, Tedjo;
- Loh, Kim;
- Tremblay, Michel L.;
- Godfrey, Dale I.;
- Sims, Natalie A.;
- Tiganis, Tony
Publication type:
Article
The structural basis for autonomous dimerization of the pre-T-cell antigen receptor.
Published in:
Nature, 2010, v. 467, n. 7317, p. 844, doi. 10.1038/nature09448
By:
- Siew Siew Pang;
- Berry, Richard;
- Zhenjun Chen;
- Lars Kjer-Nielsen;
- Matthew A. Perugini;
- King, Glenn F.;
- Christina Wang;
- Sock Hui Chew;
- La Gruta, Nicole L.;
- Williams, Neal K.;
- Beddoe, Travis;
- Tiganis, Tony;
- Cowieson, Nathan P.;
- Godfrey, Dale I.;
- Purcell, Anthony W.;
- Wilce, Matthew C. J.;
- McCluskey, James;
- Rossjohn, Jamie
Publication type:
Article
Stepwise progression of β-selection during T cell development involves histone deacetylation.
Published in:
Life Science Alliance, 2023, v. 6, n. 1, p. 1, doi. 10.26508/lsa.202201645
By:
- Chann, Anchi S.;
- Charnley, Mirren;
- Newton, Lucas M.;
- Newbold, Andrea;
- Wiede, Florian;
- Tiganis, Tony;
- Humbert, Patrick O.;
- Johnstone, Ricky W.;
- Russell, Sarah M.
Publication type:
Article
Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants.
Published in:
FEBS Journal, 2017, v. 284, n. 14, p. 2231, doi. 10.1111/febs.14118
By:
- Willoughby, Lee F.;
- Manent, Jan;
- Allan, Kirsten;
- Lee, Han;
- Portela, Marta;
- Wiede, Florian;
- Warr, Coral;
- Meng, Tzu‐Ching;
- Tiganis, Tony;
- Richardson, Helena E.
Publication type:
Article
Special Issue - Signalling. Introduction: Frontiers in cell signalling.
Published in:
FEBS Journal, 2013, v. 280, n. 21, p. 5163, doi. 10.1111/febs.12508
By:
- Daly, Roger;
- Tiganis, Tony
Publication type:
Article
PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis.
Published in:
FEBS Journal, 2013, v. 280, n. 2, p. 445, doi. 10.1111/j.1742-4658.2012.08563.x
By:
- Tiganis, Tony
Publication type:
Article
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.
Published in:
2019
By:
- Svensson, Mattias N. D.;
- Doody, Karen M.;
- Schmiedel, Benjamin J.;
- Bhattacharyya, Sourya;
- Panwar, Bharat;
- Wiede, Florian;
- Yang, Shen;
- Santelli, Eugenio;
- Wu, Dennis J.;
- Sacchetti, Cristiano;
- Gujar, Ravindra;
- Seumois, Gregory;
- Kiosses, William B.;
- Aubry, Isabelle;
- Kim, Gisen;
- Mydel, Piotr;
- Sakaguchi, Shimon;
- Kronenberg, Mitchell;
- Tiganis, Tony;
- Tremblay, Michel L.
Publication type:
journal article
Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.
Published in:
Angewandte Chemie, 2023, v. 135, n. 22, p. 1, doi. 10.1002/ange.202303818
By:
- Dong, Jiajun;
- Miao, Jinmin;
- Miao, Yiming;
- Qu, Zihan;
- Zhang, Sheng;
- Zhu, Peipei;
- Wiede, Florian;
- Jassim, Brenson A.;
- Bai, Yunpeng;
- Nguyen, Quyen;
- Lin, Jianping;
- Chen, Lan;
- Tiganis, Tony;
- Tao, W. Andy;
- Zhang, Zhong‐Yin
Publication type:
Article
Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase.
Published in:
Nature Immunology, 2005, v. 6, n. 3, p. 253, doi. 10.1038/ni1169
By:
- van Vliet, Catherine;
- Bukczynska, Patricia E;
- Puryer, Michelle A;
- Sadek, Christine M;
- Shields, Benjamin J;
- Tremblay, Michel L;
- Tiganis, Tony
Publication type:
Article
Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.
Published in:
International Journal of Cancer, 2003, v. 105, n. 3, p. 331, doi. 10.1002/ijc.11085
By:
- Manuela Klingler-Hoffmann;
- Patricia Bukczynska;
- Tony Tiganis
Publication type:
Article
PTPN2 attenuates T-cell lymphopenia-induced proliferation.
Published in:
Nature Communications, 2014, v. 5, n. 1, p. 3073, doi. 10.1038/ncomms4073
By:
- Wiede, Florian;
- La Gruta, Nicole L.;
- Tiganis, Tony
Publication type:
Article
Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T‐Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy.
Published in:
Angewandte Chemie International Edition, 2023, v. 62, n. 22, p. 1, doi. 10.1002/anie.202303818
By:
- Dong, Jiajun;
- Miao, Jinmin;
- Miao, Yiming;
- Qu, Zihan;
- Zhang, Sheng;
- Zhu, Peipei;
- Wiede, Florian;
- Jassim, Brenson A.;
- Bai, Yunpeng;
- Nguyen, Quyen;
- Lin, Jianping;
- Chen, Lan;
- Tiganis, Tony;
- Tao, W. Andy;
- Zhang, Zhong‐Yin
Publication type:
Article
Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway in Drosophila.
Published in:
Genetics, 2018, v. 208, n. 4, p. 1523, doi. 10.1534/genetics.117.300601
By:
- Henstridge, Michelle A.;
- Aulsebrook, Lucinda;
- Takashi Koyama;
- Johnson, Travis K.;
- Whisstock, James C.;
- Tiganis, Tony;
- Mirth, Christen K.;
- Warr, Coral G.
Publication type:
Article
Structure guided studies of the interaction between PTP1B and JAK.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05020-9
By:
- Morris, Rhiannon;
- Keating, Narelle;
- Tan, Cyrus;
- Chen, Hao;
- Laktyushin, Artem;
- Saiyed, Tamanna;
- Liau, Nicholas P. D.;
- Nicola, Nicos A.;
- Tiganis, Tony;
- Kershaw, Nadia J.;
- Babon, Jeffrey J.
Publication type:
Article
PTPN2: a tumor suppressor you want deleted?
Published in:
Immunology & Cell Biology, 2017, v. 95, n. 10, p. 859, doi. 10.1038/icb.2017.70
By:
- Wiede, Florian;
- Tiganis, Tony
Publication type:
Article
Protein Tyrosine Phosphatases: Dephosphorylating the Epidermal Growth Factor Receptor.
Published in:
IUBMB Life, 2002, v. 53, n. 1, p. 3, doi. 10.1080/15216540210811
By:
- Tiganis, Tony
Publication type:
Article
Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase.
Published in:
1997
By:
- Kobe, Bostjan;
- House, Colin M.;
- Feil, Susanne C.;
- Michell, Belinda J.;
- Tiganis, Tony;
- Parker, Michael W.;
- Kemp, Bruce E.;
- Cotton, Richard G.H.;
- Jennings, Ian G.
Publication type:
Other
Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis.
Published in:
Cell Communication & Signaling, 2014, v. 12, n. 1, p. 1, doi. 10.1186/1478-811X-12-13
By:
- Bettaieb, Ahmed;
- Yannan Xi;
- Hosein, Ellen;
- Coggins, Nicole;
- Bachaalany, Santana;
- Wiede, Florian;
- Perez, Salvador;
- Griffey, Stephen M.;
- Sastre, Juan;
- Tiganis, Tony;
- Haj, Fawaz G.
Publication type:
Article
T-Cell–Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities.
Published in:
Diabetes, 2019, v. 68, n. 6, p. 1251, doi. 10.2337/db18-1362
By:
- Wiede, Florian;
- Brodnicki, Thomas C.;
- Pei Kee Goh;
- Leong, Yew A.;
- Jones, Gareth W.;
- Di Yu;
- Baxter, Alan G.;
- Jones, Simon A.;
- Kay, Thomas W. H.;
- Tiganis, Tony
Publication type:
Article
T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities.
Published in:
2019
By:
- Wiede, Florian;
- Brodnicki, Tom;
- Goh, Pei Kee;
- Leong, Yew A;
- Jones, Gareth W;
- Yu, Di;
- Baxter, Alan G;
- Jones, Simon A;
- Kay, Tom;
- Tiganis, Tony;
- Brodnicki, Thomas C;
- Kay, Thomas W H
Publication type:
journal article
Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465.
Published in:
2019
By:
- Pfuhlmann, Katrin;
- Schriever, Sonja C.;
- Baumann, Peter;
- Kabra, Dhiraj G.;
- Harrison, Luke;
- Mazibuko-Mbeje, Sithandiwe E.;
- Contreras, Raian E.;
- Kyriakou, Eleni;
- Simonds, Stephanie E.;
- Tiganis, Tony;
- Cowley, Michael A.;
- Woods, Stephen C.;
- Jastroch, Martin;
- Clemmensen, Christoffer;
- De Angelis, Meri;
- Schramm, Karl-Werner;
- Sattler, Michael;
- Messias, Ana C.;
- Tschöp, Matthias H.;
- Pfluger, Paul T.
Publication type:
journal article
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.
Published in:
2018
By:
- Pfuhlmann, Katrin;
- Schriever, Sonja C.;
- Baumann, Peter;
- Kabra, Dhiraj G.;
- Harrison, Luke;
- Mazibuko-Mbeje, Sithandiwe E.;
- Contreras, Raian E.;
- Kyriakou, Eleni;
- Simonds, Stephanie E.;
- Tiganis, Tony;
- Cowley, Michael A.;
- Woods, Stephen C.;
- Jastroch, Martin;
- Clemmensen, Christoffer;
- De Angelis, Meri;
- Schramm, Karl-Werner;
- Sattler, Michael;
- Messias, Ana C.;
- Tschöp, Matthias H.;
- Pfluger, Paul T.
Publication type:
journal article
TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding.
Published in:
2018
By:
- Dodd, Garron T.;
- Lee-Young, Robert S.;
- Brüning, Jens C.;
- Tiganis, Tony
Publication type:
journal article
Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets.
Published in:
Diabetes, 2015, v. 64, n. 7, p. 2489, doi. 10.2337/db14-1575
By:
- Stanley, William J.;
- Litwak, Sara A.;
- Hong Sheng Quah;
- Sih Min Tan;
- Kay, Thomas W. H.;
- Tiganis, Tony;
- de Haan, Judy B.;
- Thomas, Helen E.;
- Gurzov, Esteban N.
Publication type:
Article
The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity.
Published in:
2012
By:
- Visinoni S;
- Khalid NF;
- Joannides CN;
- Shulkes A;
- Yim M;
- Whitehead J;
- Tiganis T;
- Lamont BJ;
- Favaloro JM;
- Proietto J;
- Andrikopoulos S;
- Fam BC;
- Visinoni, Sherley;
- Khalid, Nurul Fathiah Izzati;
- Joannides, Christos N;
- Shulkes, Arthur;
- Yim, Mildred;
- Whitehead, Jon;
- Tiganis, Tony;
- Lamont, Benjamin J
Publication type:
journal article
The Role of Liver Fructose-1,6-Bisphosphatase in Regulating Appetite and Adiposity.
Published in:
Diabetes, 2012, v. 61, n. 5, p. 1122, doi. 10.2337/db11-1511
By:
- Visinoni, Sherley;
- Khalid, Nurul Fathiah Izzati;
- Joannides, Christos N.;
- Shulkes, Arthur;
- Yim, Mildred;
- Whitehead, Jon;
- Tiganis, Tony;
- Lamont, Benjamin J.;
- Favaloro, Jenny M.;
- Proietto, Joseph;
- Andrikopoulos, Sofianos;
- Fam, Barbara C.
Publication type:
Article
T-Cell Protein Tyrosine Phosphatase Attenuates STAT3 and Insulin Signaling in the Liver to Regulate Gluconeogenesis.
Published in:
Diabetes, 2010, v. 59, n. 8, p. 1906, doi. 10.2337/db09-1365
By:
- Fukushima, Atsushi;
- Loh, Kim;
- Galic, Sandra;
- Fam, Barbara;
- Shields, Ben;
- Wiede, Florian;
- Tremblay, Michel L.;
- Watt, Matthew J.;
- Andrikopoulos, Sofianos;
- Tiganis, Tony
Publication type:
Article

Found: 39