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- Title
Hormonal Korunma, Nöbetler ve Antiepileptik İlaçlar.
- Authors
ATAKLI, Dilek
- Abstract
Contraception is an important consideration for women with epilepsy. The pharmacokinetic interactions between antiepileptic drugs and oral contraceptives are biderectional. Steroid hormones and enzyme-inducing antiepileptic drugs are substrates for the cytochrome P450 enzyme system. As a result, the concomitant use of hormonal contraceptives and antiepileptic drugs may pose a risk for unexpected pregnancy and seizures. Intrauterine devices and barrier methods are appropriate to recommend for use in women using enzyme-inducing medications. Depot medroxyprogesterone acetate injections appear to be effective; however, they may not be the first choice due to serious effects. Oral contraceptives significantly increase the metabolism of lamotrigine. Therefore, women with epilepsy taking lamotrigine need to be monitored carefully.
- Subjects
MEDROXYPROGESTERONE; CONVULSIONS -- Risk factors; RISK factors of spasms; ANTICONVULSANTS; CONTRACEPTION; SEIZURES (Medicine); DRUG interactions; INTRAUTERINE contraceptives; MEDICAL care; ORAL contraceptives; PATIENTS; SPASMS; LAMOTRIGINE; UNPLANNED pregnancy; CYTOCHROME P-450; THERAPEUTICS
- Publication
Epilepsi: Journal of the Turkish Epilepsi Society, 2018, Vol 24, p23
- ISSN
1300-7157
- Publication type
Article
- DOI
10.14744/epilepsi.2018.07769