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- Title
L-Fucose Suppresses Lipid Accumulation via the AMPK Pathway in 3T3-L1 Adipocytes.
- Authors
Nakao, Tomohiko; Otaki, Shiro; Kominami, Yuri; Watanabe, Soichi; Ito, Miho; Aizawa, Teruki; Akahori, Yusuke; Ushio, Hideki
- Abstract
L-fucose (Fuc), a monosaccharide with different biological functions in various organisms, exhibits potent anti-obesity effects in obese mice. However, the mechanisms underlying its anti-obesity effects remain largely unknown. In this study, we aimed to investigate the effects of Fuc on lipid metabolism and insulin signaling in 3T3-L1 adipocytes. We found that Fuc treatment suppressed lipid accumulation during adipocyte differentiation. Additionally, Fuc treatment enhanced the phosphorylation of AMP-activated kinase (AMPK) and its downstream pathways, responsible for the regulation of fatty acid oxidation and lipolysis. Furthermore, Fuc-induced activation of the AMPK pathway was diminished by the AMPK inhibitor Compound C, and Fuc treatment considerably promoted glucose uptake via Akt activation in an insulin-resistant state. These findings provide a basis for elucidating the mechanism underlying the anti-obesity effect of Fuc, which may, in the future, be considered as a therapeutic compound for treating obesity and related diseases.
- Subjects
OBESITY; AMP-activated protein kinases; ANIMAL experimentation; GENETIC disorders; BLOOD sugar; CELL physiology; INSULIN; CELLULAR signal transduction; FAT cells; RESEARCH funding; DEOXY sugars; LIPID metabolism disorders; HEXOSES; MICE; FATTY acids; PHOSPHORYLATION; LIPIDS
- Publication
Nutrients, 2023, Vol 15, Issue 3, p503
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu15030503