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- Title
Impact of Early Nutrient Intake and First Year Growth on Neurodevelopment of Very Low Birth Weight Newborns.
- Authors
Brinkis, Rasa; Albertsson-Wikland, Kerstin; Tamelienė, Rasa; Aldakauskienė, Ilona; Rimdeikienė, Inesa; Marmienė, Vitalija; Šmigelskas, Kastytis; Verkauskienė, Rasa
- Abstract
Optimal nutrient intake ensuring better neurodevelopment for very low birth weight (VLBW) infants remains unknown. The aim of this study was to assess the relationship between early (first 28 days) nutritional intake, first year growth, and neurodevelopment. In total, 120 VLBW infants were included into the study. A group of 95 infants completed follow-up to 12 months of corrected gestational age (CGA). Nutrient intake was assessed, and weight, length, and head circumference (HC) were measured weekly until discharge and at 3, 6, 9, and 12 months of CGA. Neurodevelopment was assessed at 12 months of CGA. Two groups—extremely preterm (EP) and very/moderately preterm (VP)—were compared. Growth before discharge was slower in the EP group than the VP group. At 12 months, there was no difference in anthropometric characteristics or neurodevelopmental scores between the groups. Higher carbohydrate intake during the first 28 days was the single significant predictor for better cognitive scores only in the EP group (βs = 0.60, p = 0.017). Other nutrients and growth before discharge were not significant for cognitive and motor scores in either group in multivariable models, whereas post-discharge HC growth was associated with both cognitive and motor scores in the VP group. Monitoring intake of all nutrients and both pre-discharge and post-discharge growth is essential for gaining knowledge about individualized nutrition for optimal neurodevelopment.
- Subjects
PATIENT aftercare; INFANT development; BODY weight; ANTHROPOMETRY; MULTIVARIATE analysis; NUTRITIONAL requirements; VERY low birth weight; GESTATIONAL age; COGNITION; NEURAL development; CEPHALOMETRY; DIETARY carbohydrates; DISCHARGE planning; MOTOR ability; EVALUATION
- Publication
Nutrients, 2022, Vol 14, Issue 18, pN.PAG
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14183682