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- Title
Selenium and Coenzyme Q 10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial.
- Authors
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan O.; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban
- Abstract
Short telomeres have been associated with ageing and cardiovascular disease. The influence on leukocyte telomere length (LTL) of long-term intervention with combined selenium and coenzyme Q10 is unknown. Our aim was to determine whether 42 months of selenium and coenzyme Q10 supplementation prevented telomere attrition and further cardiovascular mortality. The investigation is an explorative sub-study of a double-blind, placebo-controlled, randomized trial. Swedish citizens low in selenium (n = 118), aged 70–80 years, were included. Intervention time was 4 years, with 10 years' follow-up time. LTL was relatively quantified with PCR at baseline and after 42 months. At baseline, LTL (SD) was 0.954 (0.260) in the active treatment group and 1.018 (0.317) in the placebo group (p = 0.23). At 42 months, less shortening of LTL was observed after active treatment compared with placebo (+0.019 vs. −0.129, respectively, p = 0.02), with a significant difference in change basing the analysis on individual changes in LTL (p < 0.001). Subjects suffering future death presented with significantly shorter LTL at 42 months than survivors [0.791 (0.190) vs. 0.941 (0.279), p = 0.01], with a significant difference in change of LTL according to cardiovascular mortality and survival (p = 0.03). To conclude, preservation of LTL after selenium and coenzyme Q10 supplementation associated with reduced cardiovascular mortality.
- Subjects
SWEDEN; THERAPEUTIC use of ubiquinones; CARDIOVASCULAR disease prevention; CARDIOVASCULAR disease related mortality; TELOMERES; CARDIOVASCULAR diseases; UBIQUINONES; RANDOMIZED controlled trials; DIETARY supplements; OXIDATIVE stress; MITOCHONDRIA; STATISTICAL sampling; POLYMERASE chain reaction; SELENIUM
- Publication
Nutrients, 2022, Vol 14, Issue 16, p3346
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14163346