We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Probiotic Supplementation and Micronutrient Status in Healthy Subjects: A Systematic Review of Clinical Trials.
- Authors
Barkhidarian, Bahareh; Roldos, Lucas; Iskandar, Michèle M.; Saedisomeolia, Ahmad; Kubow, Stan
- Abstract
Micronutrient deficiencies are a worldwide public health concern. Emerging evidence supports the ability of probiotics to enhance micronutrient status, which could aid in the prevention of non-communicable disease-associated malnutrition. This systematic review evaluated evidence of the efficacy of probiotic supplementation to improve micronutrient status in healthy subjects. The authors searched for published English language peer-reviewed journal articles in PubMed, Scopus, Embase, and Google Scholar databases from inception to July 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality of eligible studies was assessed using the Revised Cochrane Risk-of-Bias tool (RoB)2 and Risk of Bias in Non-Randomized Studies of Interventions tool (ROBINS-I tool). Fourteen original studies out of 2790 met the inclusion criteria. The results indicated that, despite varying degrees of efficacy, the intake of certain probiotics in healthy subjects was associated with a positive impact on the status of certain micronutrients (vitamin B12, calcium, folate, iron and zinc). A limitation was that studies were widely heterogeneous in terms of participant age, probiotic strain, species, dosage, intervention duration, and form of administration. Additional clinical trials are warranted to determine the most effective strains of probiotics, doses and durations of interventions.
- Subjects
PREVENTION of malnutrition; ONLINE information services; NON-communicable diseases; MEDICAL information storage &; retrieval systems; SYSTEMATIC reviews; PROBIOTICS; DIETARY supplements; DESCRIPTIVE statistics; MICRONUTRIENTS; MEDLINE; DATA analysis software; NUTRITIONAL status; DISEASE complications
- Publication
Nutrients, 2021, Vol 13, Issue 9, p3001
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13093001