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- Title
Inflammatory Potential of the Diet and Incidence of Crohn's Disease and Ulcerative Colitis in the EPIC-Spain Cohort.
- Authors
Guevara, Marcela; Salamanca-Fernández, Elena; Miqueleiz, Estrella; Gavrila, Diana; Amiano, Pilar; Bonet, Catalina; Rodríguez-Barranco, Miguel; Huerta, José María; Bujanda, Luis; Sánchez, María José; Chirlaque, María Dolores; Agudo, Antonio; Ardanaz, Eva; Castilla, Jesús
- Abstract
Diet may influence the development of inflammatory bowel disease through the modulation of inflammation. We investigated whether the inflammatory potential of the diet is associated with the risk of Crohn's disease (CD) and ulcerative colitis (UC) in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). The study included 32,633 participants aged 29–69 years. The inflammatory potential of the diet was measured by using an inflammatory score of the diet (ISD) based on a baseline dietary history questionnaire. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). During 21 years (674,547 person-years) of follow-up, 32 and 57 participants developed CD and UC, respectively. In multivariable analysis, a one-standard deviation (SD) increment in the ISD (two-unit increase) was associated with a higher risk of CD (HR of 1.71; 95% CI: 1.05–2.80; p = 0.031). By contrast, ISD was not associated with UC (HR for one-SD increment of 0.89; 95% CI: 0.66–1.19; p = 0.436). Our results suggest that consuming a more pro-inflammatory diet may contribute to the risk of CD, supporting that a healthy diet might be beneficial in its prevention. Further, larger studies are needed to verify these findings.
- Subjects
SPAIN; CROHN'S disease; ULCERATIVE colitis; CONFIDENCE intervals; INFLAMMATION; MULTIVARIATE analysis; TIME; DIET; DISEASE incidence; RISK assessment; QUESTIONNAIRES; PROPORTIONAL hazards models; LONGITUDINAL method; DISEASE risk factors; DISEASE complications
- Publication
Nutrients, 2021, Vol 13, Issue 7, p2201
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13072201