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- Title
Dietary Curdlan Enhances Bifidobacteria and Reduces Intestinal Inflammation in Mice.
- Authors
Rahman, Shafaque; Davids, Mark; van Hamersveld, Patricia H. P.; Welting, Olaf; Rahaoui, Hakim; Schuren, Frank; Meijer, Sybren L.; van den Wijngaard, René M.; Hakvoort, Theodorus B. M.; de Jonge, Wouter J.; Heinsbroek, Sigrid E. M.; Wolf, Federica I.; Petito, Valentina; Trapani, Valentina; Scaldaferri, Franco
- Abstract
β-glucan consumption is known for its beneficial health effects, but the mode of action is unclear. While humans and mice lack the required enzymes to digest β-glucans, certain intestinal microbes can digest β-glucans, triggering gut microbial changes. Curdlan, a particulate β-glucan isolated from Alcaligenes faecalis, is used as a food additive. In this study we determined the effect of curdlan intake in mice on the intestinal microbiota and dextran sodium sulfate (DSS)-induced intestinal inflammation. The effect of curdlan on the human intestinal microbiota was assessed using i-screen, an assay for studying anaerobic microbial interactions. Mice received oral gavage with vehicle or curdlan for 14 days followed by DSS for 7 days. The curdlan-fed group showed reduced weight loss and colonic inflammation compared to the vehicle-fed group. Curdlan intake did not induce general microbiota community changes, although a specific Bifidobacterium, closely related to Bifidobacterium choerinum, was observed to be 10- to 100-fold more prevalent in the curdlan-fed group under control and colitis conditions, respectively. When tested in i-screen, curdlan induced a global change in the microbial composition of the healthy intestinal microbiota from a human. Overall, these results suggest that dietary curdlan induces microbiota changes that could reduce intestinal inflammation.
- Subjects
INFLAMMATION prevention; BIFIDOBACTERIUM; GUT microbiome; INFLAMMATION; ANIMAL experimentation; INGESTION; BETA-glucans; WEIGHT loss; DISEASE prevalence; INTESTINES; DEXTRAN; MICE; ANAEROBIC bacteria
- Publication
Nutrients, 2021, Vol 13, Issue 4, p1305
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13041305