We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Serum Adipokines, Growth Factors, and Cytokines Are Independently Associated with Stunting in Bangladeshi Children.
- Authors
Hossain, Muttaquina; Nahar, Baitun; Haque, Md. Ahshanul; Mondal, Dinesh; Mahfuz, Mustafa; Naila, Nurun Nahar; Gazi, Md. Amran; Hasan, Md. Mehedi; Haque, Nur Muhammad Shahedul; Haque, Rashidul; Arndt, Michael B; Walson, Judd L; Ahmed, Tahmeed
- Abstract
Growth in young children is controlled through the release of several hormonal signals, which are affected by diet, infection, and other exposures. Stunting is clearly a growth disorder, yet limited evidence exists documenting the association of different growth biomarkers with child stunting. This study explored the association between different growth biomarkers and stunting in Bangladeshi children. A quasi-experimental study was conducted among 50 stunted (length-for-age Z-score (LAZ) < −2 SD) and 50 control (LAZ ≥ −2 SD) children, aged 12–18 months, residing in a Bangladeshi slum. The enrolled stunted children received an intervention package, which included food supplementation for three months, psychosocial stimulation for six months, and routine clinical care on community nutrition center at the study field site. The controls received routine clinical care only. All children were clinically screened over the study period. Length, weight, fasting blood and fecal biomarkers were measured. All biomarkers levels were similar in both groups except for oxyntomodulin at enrolment. Leptin (adjusted odds ratio, AOR: 4.0, p < 0.01), leptin–adiponectin ratio (AOR 5.07 × 108, p < 0.01), insulin-like growth factor-1 (IGF-1) (AOR 1.02, p < 0.05), and gamma interferon (IFN-γ) (AOR 0.92, p < 0.05) levels were independently associated with stunting at enrolment. Serum leptin, leptin–adiponectin ratio, interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-α), and fecal alpha-1-antitrypsin (AAT) levels increased significantly (p < 0.001), while IFN-γ levels significantly decreased among stunted children after six months of intervention. Leptin, leptin–adiponectin ratio, IGF-1, and IFN-γ are independently associated with stunting in Bangladeshi children. This trial was registered at clinicaltrials.gov as NCT02839148.
- Subjects
BANGLADESH; BIOMARKERS; CLINICAL trials; CYTOKINES; DIETARY supplements; GROWTH disorders; GROWTH factors; INTERFERONS; INTERLEUKINS; RESEARCH methodology; TIME; TUMOR necrosis factors; LEPTIN; CONNECTIVE tissue growth factor; ADIPOKINES; DESCRIPTIVE statistics; ODDS ratio
- Publication
Nutrients, 2019, Vol 11, Issue 8, p1827
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu11081827