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- Title
H‐Dimeric Nanospheres of Amphipathic Squaraine Dye with an 81.2% Photothermal Conversion Efficiency for Photothermal Therapy.
- Authors
Wang, Yigang; Xia, Guomin; Tan, Manman; Wang, Mingda; Li, Yingzhong; Wang, Hongming
- Abstract
Understanding and implementing the ordered supramolecular assembly in organic photothermal materials is challenging, yet significant, for photothermal performance enhancement. Herein, an amphipathic squaraine dye (PSQ) with a poly (ethylene glycol) chain attached as a hydrophilic anchor is synthesized. In aqueous solution, PSQ spontaneously self‐assembles into uniform nanospheres (PSQ‐NSs) with well‐defined H‐dimeric substructures. Molecular dynamics simulations are conducted to illustrate the self‐assembly process. Reorganization energy calculations show that nonradiative decay is accelerated by H‐dimeric PSQ low‐frequency out‐of‐plane vibrational modes, which enables a rapid dissipation of excited‐state energy to heat. As such, the resultant H‐dimeric PSQ‐NSs exhibit ultrahigh photothermal conversion efficiency (81.2%) under laser irradiation (0.3 W cm−2, 808 nm) in water. In vitro and in vivo evaluations confirm their high stability, biocompatibility, tumor accumulation, and efficient tumor inhibition in photothermal therapy. It is expected that the self‐assembling H‐dimers will become a unique platform for the precise designing of small‐molecule PTAs for future clinical PTT applications.
- Subjects
PHOTOTHERMAL conversion; MOLECULAR dynamics; REORGANIZATION energy; ETHYLENE glycol; ENERGY dissipation
- Publication
Advanced Functional Materials, 2022, Vol 32, Issue 25, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202113098