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- Title
Alternatives to the Randomized Controlled Trial.
- Authors
West, Stephen G.; Duan, Naihua; Pequegnat, Willo; Gaist, Paul; Jarlais, Don C. Des; Holtgrave, David; Szapocznik, José; Fishbein, Martin; Rapkin, Bruce; Clatts, Michael; Mullen, Patricia Dolan
- Abstract
Public health researchers are addressing new research questions (e.g., effects of environmental tobacco smoke. Hurricane Katrina) for which the randomized controlled trial (RCT) may not be a feasible option. Drawing on the potential outcomes framework (Rubin Causal Model) and Campbellian perspectives, we consider alternative research designs that permit relatively strong causal inferences. In randomized encouragement designs, participants are randomly invited to participate in one of the treatment conditions, but are allowed to decide whether to receive treatment. In quantitative assignment designs, treatment is assigned on the basis of a quantitative measure (e.g., need, merit, risk). In observational studies, treatment assignment is unknown and presumed to be nonrandom. Major threats to the validity of each design and statistical strategies for mitigating those threats are presented. [Am J Public Health. 2008;98:1359-1366. doi:10.2105/AJPH.2007.124446)
- Subjects
CLINICAL trials; MEDICAL research; EXPERIMENTAL design; SCIENTIFIC observation; SCIENTIFIC method; TOBACCO smoke pollution; HURRICANE Katrina, 2005; PUBLIC health; MEDICAL care
- Publication
American Journal of Public Health, 2008, Vol 98, Issue 8, p1359
- ISSN
0090-0036
- Publication type
Article
- DOI
10.2105/AJPH.2007.124446