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- Title
Overexpression of interleukin-1β and interleukin-6 may play an important role in periodontal breakdown in type 2 diabetic patients.
- Authors
Duarte, P. M.; De Oliveira, M. C. G.; Tambeli, C. H.; Parada, C. A.; Casati, M. Z.; Nociti, F. H.
- Abstract
Background and Objective: This study evaluated whether the biochemical changes associated with type 2 diabetes modulate the expression of interleukin-1β, interleukin-6, interleukin-8, and interferon-γ in sites with chronic periodontitis. Material and Methods: Biopsies were harvested and divided into three groups: group 1, systemically and periodontally healthy subjects ( n = 10); group 2, systemically healthy subjects with moderate-to-severe chronic periodontitis (probing depth > 6 mm) ( n = 20); and group 3, type 2 diabetic subjects with periodontitis ( n = 20). Cytokine levels were assessed in the gingival tissues by enzyme-linked immunosorbent assay analysis. Results: Data analysis demonstrated that the interleukin-1β, interleukin-6, interleukin-8, and interferon-γ levels were higher in the presence of periodontal inflammation than in the absence of inflammation, regardless of systemic status. The interleukin-1β and interleukin-6 levels were higher in diabetic subjects (group 3) than in systemically healthy patients with comparable types of periodontitis (group 2). No difference was observed for the interleukin-8 and interferon-γ levels between groups 2 and 3. Conclusion: Within the limits of this study, it was concluded that type 2 diabetes was associated with increased expression of interleukin-1β and interleukin-6 in periodontally inflamed tissues of diabetic patients, relative to nondiabetic subjects, and that such overexpression may be involved in the mechanisms by which type 2 diabetes enhances periodontal destruction.
- Subjects
INTERLEUKINS; PEOPLE with diabetes; TYPE 2 diabetes; PERIODONTAL disease; CHRONIC diseases; CYTOKINES; ENZYME-linked immunosorbent assay
- Publication
Journal of Periodontal Research, 2007, Vol 42, Issue 4, p377
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/j.1600-0765.2006.00961.x