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- Title
Neonatal Pulmonary Hypertension.
- Authors
Giang Truong; Lo, Jennifer; Merritt, T. Allen; Goldstein, Mitchell
- Abstract
Neonatal pulmonary hypertension, also known as persistent pulmonary hypertension in the newborn (PPHN), is characterized by elevated pulmonary vascular resistance resulting in hypoxemia. Labile hypoxemia and differential cyanosis are clinical signs of pulmonary hypertension. An echocardiogram is the best study to confirm the diagnosis of PPHN. Management is mainly supportive with goals to recruit optimal lung volume, stabilize blood pressure, optimize oxygenation, reduce shunting, sedate when indicated, and correct acidosis. There are multiple available pulmonary vasodilators. Despite maximal intervention, some patients require extracorporeal membrane oxygenation (ECMO). The purpose of this paper is to review (1) fetal, transitional and postnatal cardiovascular physiology; (2) pulmonary hypertension pathogenesis; (3) clinical presentation, diagnosis, treatment and outcomes in patients with pulmonary hypertension. (1,2).
- Subjects
PERSISTENT fetal circulation syndrome; EXTRACORPOREAL membrane oxygenation; TREATMENT effectiveness; LUNG volume; CYANOSIS in children
- Publication
Neonatology Today, 2019, Vol 14, Issue 2, p50
- ISSN
1932-7129
- Publication type
Article