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- Title
HIGH EXPRESSION LEVEL OF MIR-1260 FAMILY IN THE PERIPHERAL BLOOD OF PATIENTS WITH OVARIAN CANCER.
- Authors
Ghafour, Arash Adamnejad; Avsar, Mukaddes; Tuncer, Seref Bugra; Kurt, Busra; Kilic, Seda; Erdogan, Ozge Sukruoglu; Kuru, Gozde; Celik, Betul; Odemis, Demet Akdeniz; Saip, Pınar; Yazici, Hulya
- Abstract
OBJECTIVES: According to TUIK-Turkish statistics, every year around 2790 OvarianCancer cases have been reported in Turkey. In order to have effective treatment of OvarianCancer as well as to follow the treatment process and to diagnose in early stage, there is need for disease-specific and sensitive biomarkers. This study aims to determine whether miR1260a and miR1260b molecules can be non-invasive biomarkers for sporadic and familial OvarianCancer cases compared with healthy controls. MATERIAL&METHODS: The expression levels of miR1260a and miR1260b were investigated in 150 patients with familial and sporadic OvarianCancer, and 100 healthy controls matched with patients for age, gender, ethnicity. RESULTS: It was seen that there was a statistically significant difference (p = 0.000) for expression levels of both miRNAs between the ovarian cancer patients and the healthy control group. According to healthy controls, it was found that the expression of miR-1260a and miR-1260b in OvarianCancer patients increased between 16.1-43.21 fold. STRING analysis was performed to understand the interactions of these molecules with other genes. It was found that miR-1260a has relationship with the ribosomal protein family known to have effect on the cellular stage of translation and miR-1260b is associated with the proteins CHEK2 and CDK4. CONCLUSIONS: The significant expression of miR-1260 and miR-1260b in peripheral blood lymphocytes of patients with ovarian cancer compared to healthy controls was shown first. The miR-1260 and miR-1260b molecules may be responsible for the etiology of ovarian cancer. It is thought that miR1260 and miR1260b molecules may be used as non-invasive biomarkers for diagnosis and prognosis of OvarianCancer.
- Subjects
TURKEY; OVARIAN cancer; CANCER patients; RIBOSOMAL proteins; ETIOLOGY of cancer; BLOOD; GENETIC translation; CANCER prognosis
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2019, Vol 44, p62
- ISSN
0250-4685
- Publication type
Article